ArticleMammalian genome : official journal of the International Mammalian Genome Society2016
Evidence of selection signatures that shape the Persian cat breed.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Role of CNTN6 in neurodevelopment and neuropathology.Frontiers in neuroscience · 2026Review
- Chromosome-scale assembly with improved annotation provides insights into breed-wide genomic structure and diversity in domestic cats.Journal of advanced research · 2025Article
- Copy-cat evolution: Divergence and convergence within and between cat and dog breeds.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Evaluation of Radiological and Anatomical Features of Cervical Vertebrae in Adult Persian Cat.Veterinary medicine and science · 2024Article
- An ancient haplotype containing antimicrobial peptide gene variants is associated with severe fungal skin disease in Persian cats.PLoS genetics · 2022Article
- Facial conformation characteristics in Persian and Exotic Shorthair cats.Journal of feline medicine and surgery · 2021Article
- More Than a Moggy; A Population Genetics Analysis of the United Kingdom's Non-Pedigree Cats.Genes · 2021Article
- A publicly available repository of ROH islands reveals signatures of selection in different livestock and pet species.Genetics, selection, evolution : GSE · 2021Article
- Article
- An initial genome-wide investigation of protein-losing enteropathy in Gordon setters: Exploratory observations.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2021Article
- Patterns of allele frequency differences among domestic cat breeds assessed by a 63K SNP array.PloS one · 2021Article
- Exceptional Changes in Skeletal Anatomy under Domestication: The Case of Brachycephaly.Integrative organismal biology (Oxford, England) · 2021Article
- Unravelling selection signatures in a single dog breed suggests recent selection for morphological and behavioral traits.Advanced genetics (Hoboken, N.J.) · 2020Article
- Ancestry-Dependent Enrichment of Deleterious Homozygotes in Runs of Homozygosity.American journal of human genetics · 2019Article
- Persian cats under first opinion veterinary care in the UK: demography, mortality and disorders.Scientific reports · 2019Article
- Genome-wide patterns of homozygosity provide clues about the population history and adaptation of goats.Genetics, selection, evolution : GSE · 2018Article
- Applications and efficiencies of the first cat 63K DNA array.Scientific reports · 2018Article
- Creating diversity in mammalian facial morphology: a review of potential developmental mechanisms.EvoDevo · 2018Review
- Genome-Wide Signatures of Selection Reveal Genes Associated With Performance in American Quarter Horse Subpopulations.Frontiers in genetics · 2018Article
- Weighted likelihood inference of genomic autozygosity patterns in dense genotype data.BMC genomics · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The Persian cat is mainly characterized by an extremely brachycephalic face as part of the standard body conformation. Despite the popularity, world-wide distribution, and economic importance of the Persian cat as a fancy breed, little is known about the genetics of their hallmark morphology, brachycephaly. Over 800 cats from different breeds including Persian, non-Persian breeds (Abyssinian, Cornish Rex, Bengal, La Perm, Norwegian Forest, Maine Coon, Manx, Oriental, and Siamese), and Persian-derived breeds (British Shorthair, Scottish Fold, Selkirk Rex) were genotyped with the Illumina 63 K feline DNA array. The experimental strategy was composed of three main steps: (i) the Persian dataset was screened for runs of homozygosity to find and select highly homozygous regions; (ii) selected Persian homozygous regions were evaluated for the difference of homozygosity between Persians and those considered non-Persian breeds, and, (iii) the Persian homozygous regions most divergent from the non-Persian breeds were investigated by haplotype analysis in the Persian-derived breeds. Four regions with high homozygosity (H > 0.7) were detected, each with an average length of 1 Mb. Three regions can be considered unique to the Persian breed, with a less conservative haplotype pattern in the Persian-derived breeds. Moreover, two genes, CHL1 and CNTN6 known to determine face shape modification in humans, reside in one of the identified regions and therefore are positional candidates for the brachycephalic face in Persians. In total, the homozygous regions contained several neuronal genes that could be involved in the Persian cat behavior and can provide new insights into cat domestication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.