ArticleBMJ open2016
Mortality and use of psychotropic medication in patients with stroke: a population-wide, register-based study.
Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Stakeholders' views on the use of psychotropic medication in older people: a systematic review.Age and ageing · 2022Pooled it
- Pre-stroke sleep symptoms and neurological outcomes after stroke: an exploratory secondary analysis of two prospective cohorts.Sleep & breathing = Schlaf & Atmung · 2026Article
- Comparison of In Vitro Metrics With Real-World Risk of Drug-Induced Parkinsonism Due to Antipsychotic Drugs: Retrospective Cohort Study.JMIR public health and surveillance · 2026Article
- Psychotropic polypharmacy impairs walking independence in post-stroke patients.European journal of clinical pharmacology · 2025Article
- Pre-morbid sleep disturbance and its association with stroke severity: results from the international INTERSTROKE study.European journal of neurology · 2024Article
- Article
- Use of benzodiazepine and Z-drugs and mortality in older adults after myocardial infarction.International journal of geriatric psychiatry · 2023Article
- A Narrative Review on the Non-Pharmacologic Interventions in Post-Stroke Depression.Psychology research and behavior management · 2022Review
- Real-world data on new users of atypical antipsychotics: characterisation, prescription patterns, healthcare costs and early cardio-metabolic occurrences from a large Italian database.European journal of clinical pharmacology · 2020Article
- Neuronal Transmembrane Chloride Transport Has a Time-Dependent Influence on Survival of Hippocampal Cultures to Oxygen-Glucose Deprivation.Brain sciences · 2019Article
- Preadmission use of benzodiazepines and stroke outcomes: the Biostroke prospective cohort study.BMJ open · 2019Observational
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- Article
- Changes in psychotropic prescription medication use and their relationship with mortality among people with traumatic spinal cord injury.Spinal cord · 2018Article
- Hypnotic drug risks of mortality, infection, depression, and cancer: but lack of benefit.F1000Research · 2016Review
- Metabolic Acidosis in Multi Drug Poisoning with Antidepressants and Antipsychotics.Journal of research in pharmacy practiceArticle
- Rates and Correlations of Psychiatric Drug Administration in a Rehabilitation Center.Journal of neurosciences in rural practiceArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe study sought to describe whether psychotropic medication may have long-term side effects in patients with stroke compared with controls.
settingUse of national register data from healthcare services were identified from the Danish National Patient Registry in Denmark. Information about psychotropic medication use was obtained from the Danish Register of Medicinal Product Statistics.
objectivesWe aimed to evaluate all-cause mortality in relation to the use of benzodiazepines, antidepressants and antipsychotics in patients with stroke and matched controls.
participantsPatients with a diagnosis of stroke and either no drug use or preindex use of psychotropic medication (n=49,968) and compared with control subjects (n=86,100) matched on age, gender, marital status and community location. PRIMARY OUTCOME MEASURE: All-cause mortality.
resultsAll-cause mortality was higher in patients with previous stroke compared with control subjects. Mortality HRs were increased for participants prescribed serotonergic antidepressant drugs (HR=1.699 (SD=0.030), p=0.001 in patients; HR=1.908 (0.022), p<0.001 in controls, respectively), tricyclic antidepressants (HR=1.365 (0.045), p<0.001; HR=1.733 (0.022), p<0.001), benzodiazepines (HR=1.643 (0.040), p<0.001; HR=1.776 (0.053), p<0.001), benzodiazepine-like drugs (HR=1.776 (0.021), p<0.001; HR=1.547 (0.025), p<0.001), first-generation antipsychotics (HR=2.001 (0.076), p<0.001; HR=3.361 (0.159), p<0.001) and second-generation antipsychotics (HR=1.645 (0.070), p<0.001; HR=2.555 (0.086), p<0.001), compared with no drug use. Interaction analysis suggested statistically significantly higher mortality HRs for most classes of psychotropic drugs in controls compared with patients with stroke.
conclusionsAll-cause mortality was higher in patients with stroke and controls treated with benzodiazepines, antidepressants and antipsychotics than in their untreated counterparts. Our findings suggest that care should be taken in the use and prescription of such drugs, and that they should be used in conjunction with adequate clinical controls.
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