ArticlePlant cell reports2016
Topoisomerase II-associated protein PAT1H1 is involved in the root stem cell niche maintenance in Arabidopsis thaliana.
Article in Plant cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Identification of genetic loci associated with five agronomic traits in alfalfa using multi-environment trials.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Characteristics of theGenes · 2021Article
- Article
- NINJA-associated ERF19 negatively regulates Arabidopsis pattern-triggered immunity.Journal of experimental botany · 2019Article
- Over-expression of Topoisomerase II Enhances Salt Stress Tolerance in Tobacco.Frontiers in plant science · 2016Article
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Authors and funding
6 authors.
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Abstract
key messagePAT1H1, one of the homologues of Topoisomerase II-associated protein, is involved in the maintenance of root stem cell niche through the interaction with NINJA. The root stem cell niche, which possesses four mitotically inactive quiescent cells (QC) and the surrounding mitotically active stem cells, is critical for root development in Arabidopsis thaliana. However, the molecular regulation of the maintenance of root stem cell niche identity is still not fully understood. Here we show that one of the homologues of Topoisomerase II-associated protein, here named as PAT1H1, could regulate root stem cell niche identity. The pat1h1 mutant showed higher frequency of QC cell division and root distal stem cell (DSC) differentiation. With a high expression in roots, PAT1H1 was found to interact with the jasmonic acid (JA) signalling negative regulator Novel Interactor of JAZ (NINJA) and thus regulate root DSC niche identity. Consistent with the active QC cell division, which rarely occurs in wild-type controls, the pat1h1 mutant displayed higher expression of CYCB1 in the root stem cell niche. Together our data reveals that PAT1H1 maintains root stem cell niche stability through the interaction with NINJA and the regulation of cell division.
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