ArticleScientific reports2016
Variations in SXT elements in epidemic Vibrio cholerae O1 El Tor strains in China.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 52 citations in OpenAlex.
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- Marine bacteria harbor the sulfonamide resistance geneFrontiers in microbiology · 2023Article
- Azithromycin can induce SOS response and horizontal gene transfer of SXT element in Vibrio cholerae.Molecular biology reports · 2022Article
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- An Integrative and Conjugative Element (ICE) Found in Shewanella halifaxensis Isolated from Marine Fish Intestine May Connect Genetic Materials between Human and Marine Environments.Microbes and environments · 2022Article
- Temporal shifts in antibiotic resistance elements govern phage-pathogen conflicts.Science (New York, N.Y.) · 2021Article
- Assessment and Antibiotic Resistance Profiling inAntibiotics (Basel, Switzerland) · 2021Article
- A Vibrio cholerae Core Genome Multilocus Sequence Typing Scheme To Facilitate the Epidemiological Study of Cholera.Journal of bacteriology · 2020Article
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- Isolation, nucleotide sequencing and genomic comparison of a Novel SXT/R391 ICE mobile genetic element isolated from a municipal wastewater environment.Scientific reports · 2020Article
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- Exploration of Anti-infectives From Mangrove-DerivedFrontiers in microbiology · 2020Article
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- Cholera: an overview with reference to the Yemen epidemic.Frontiers of medicine · 2019Review
- Investigating the virulence genes and antibiotic susceptibility patterns of Vibrio cholerae O1 in environmental and clinical isolates in Accra, Ghana.BMC infectious diseases · 2019Article
- Surveillance and Genomics of ToxigenicFrontiers in microbiology · 2019Article
- Altered Integrative and Conjugative Elements (ICEs) in RecentFrontiers in microbiology · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vibrio cholerae O1 El Tor biotype strains are responsible for three multiyear epidemics of cholera in China during the seventh ongoing pandemic. The presence of the integrative conjugative element SXT is strongly correlated with resistance to nalidixic acid, tetracycline, and trimethoprim-sulfamethoxazole in these strains. Here, we sequenced the conserved genes of the SXT element, including eex, setR, and int, from 59 V. cholerae O1 El Tor strains and extracted and assembled the intact SXT sequences from the 11 genome sequenced strains. These elements had characteristics distinct from those of previously reported integrative conjugative elements (ICEs). They could be clearly divided into two types based on the clustering of conserved genes and gene structures of the elements, showing their possibly independent derivation and evolution. These two types were present before and after 2005, respectively, demonstrating the type substitution that occurred in 2005. Four to six antibiotic-resistant genes were found on the SXT elements, including genes resistant to tetracycline, trimethoprim-sulfamethoxazole, and multiple drugs. In summary, our findings demonstrated the roles of the SXT element in the emergence of multidrug resistance in epidemic O1 El Tor V. cholerae strains in China.
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