Trial reportNutrition journal2016
The effect of moderate intensity exercise in the postprandial period on the inflammatory response to a high-fat meal: an experimental study.
Trial report in Nutrition journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- The impact of an acute high polyphenol, high fiber meal with and without aerobic exercise on metabolism in middle-aged and older adults: A pilot study.Physiological reports · 2025Trial
- Preceding exercise and postprandial hypertriglyceridemia: effects on lymphocyte cell DNA damage and vascular inflammation.Lipids in health and disease · 2019Trial
- Exercise and postprandial lipemia: effects on vascular health in inactive adults.Lipids in health and disease · 2018Trial
- Does chronic physical activity level modify the airway inflammatory response to an acute bout of exercise in the postprandial period?Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2017Trial
- Effects of thirty and sixty minutes of moderate-intensity aerobic exercise on postprandial lipemia and inflammation in overweight men: a randomized cross-over study.Journal of the International Society of Sports Nutrition · 2016Trial
- Article
- Acute Exercise and the Systemic and Airway Inflammatory Response to a High-Fat Meal in Young and Older Adults.Metabolites · 2022Article
- Who would benefit most from postprandial lipid screening?Clinical nutrition (Edinburgh, Scotland) · 2021Article
- Meal-exercise challenge and physical activity reduction impact on immunity and inflammation (MERIIT trial).Contemporary clinical trials communications · 2018Article
- Postprandial Metabolic Responses Differ by Age Group and Physical Activity Level.The journal of nutrition, health & aging · 2018Article
- Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers.World journal of gastrointestinal pathophysiology · 2017Article
- Consumption of a high-fat breakfast on consecutive days alters preclinical biomarkers for atherosclerosis.European journal of clinical nutrition · 2017Article
- Postprandial lipemic and inflammatory responses to high-fat meals: a review of the roles of acute and chronic exercise.Nutrition & metabolism · 2016Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConsuming a high-fat meal (HFM) may lead to postprandial lipemia (PPL) and inflammation. Postprandial exercise has been shown to effectively attenuate PPL. However, little is known about the impact of postprandial exercise on systemic inflammation and whether PPL and inflammation are associated. The purpose of this study was to determine whether moderate intensity exercise performed 60 min following a true-to-life HFM would attenuate PPL and inflammation.
methodsThirty-nine young adults (18-40 year) with no known metabolic disease were randomized to either a control group (CON) who remained sedentary during the postprandial period or an exercise (EX) group who walked at 60 % VO2peak to expend ≈ 5 kcal/kgbw one-hour following the HFM. Participants consumed a HFM of 10 kcal/kgbw and blood draws were performed immediately before, 2 h and 4 h post-HFM.
resultsAt baseline, there were no differences between EX and CON groups for any metabolic or inflammatory markers (p > 0.05). Postprandial triglycerides (TRG) increased from baseline to 4 h in the EX and CON groups (p < 0.001), with no differences between groups (p = 0.871). High density lipoprotein cholesterol (HDL-C) decreased in both groups across time (p < 0.001) with no differences between groups (p = 0.137). Interleukin-6 (IL-6) was significant as a quadratic function over time (p = 0.005), decreasing from baseline to 2 h then increasing and returning to baseline at 4 h in all participants with no difference between groups (p = 0.276). Tumor necrosis factor-alpha (TNF-α) was not different from baseline to 4 h between groups (p > 0.05). There was an increase in soluble vascular adhesion molecule (sVCAM-1) from baseline to 4 h (p = 0.027) for all participants along with a group x time interaction (p = 0.020). Changes in TRG were associated with changes in interleukin-10 (IL-10) from 0 to 2 h (p = 0.007), but were not associated with changes in any other inflammatory marker in the postprandial period (p > 0.05).
conclusionsDespite significant increases in PPL following a HFM, moderate intensity exercise in the postprandial period did not mitigate the PPL nor the inflammatory response to the HFM. These results indicate that in populations with low metabolic risk, PPL and inflammation following a HFM may not be directly related.
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