ArticleObesity (Silver Spring, Md.)2016
Prepubertal children exposed to concentrated disadvantage: An exploratory analysis of inflammation and metabolic dysfunction.
Article in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Comparing two measures of neighborhood quality and internalizing and externalizing behaviors in the adolescent brain cognitive development study.Social psychiatry and psychiatric epidemiology · 2024Article
- An examination of the relationships between the neighborhood social environment, adiposity, and cardiometabolic disease risk in adolescence: a cross-sectional study.BMC public health · 2023Article
- Radically reframing studies on neurobiology and socioeconomic circumstances: A call for social justice-oriented neuroscience.Frontiers in integrative neuroscience · 2022Article
- Chronic Stress in Children and Adolescents: A Review of Biomarkers for Use in Pediatric Research.Biological research for nursing · 2018Article
- Neighborhood disadvantage and racial disparities in colorectal cancer incidence: a population-based study in Louisiana.Annals of epidemiology · 2018Article
- Advancing the Science of Health Disparities Through Research on the Social Determinants of Health.American journal of preventive medicine · 2017Article
- Parental Perceptions of the Social Environment Are Inversely Related to Constraint of Adolescents' Neighborhood Physical Activity.International journal of environmental research and public health · 2016Article
- Psychological Stress During Childhood and Adolescence and Its Association With Inflammation Across the Lifespan: A Critical Review and Meta-Analysis.Psychological bulletinArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveIt is unclear whether physiologic and metabolic biomarkers are associated with chronic stressors evidenced during early childhood.
methodsCross-sectional data were obtained from a cohort of healthy, prepubertal (Tanner stage < 2) children (n = 96; age: 8.06 [7.8] years; M = 51 [53%]; F = 45 [47%]; African-American = 26 [27%]; Caucasian = 70 [73%]; with obesity = 21 [22%]; without obesity = 75 [78%]) from the MET study. Body mass index z-score (z_BMI), total body fat (BF), visceral adipose tissue (VAT), intrahepatic and intramyocellular lipids, and insulin resistance (HOMA-IR) were measured. Chronic stress was assessed using neighborhood concentrated disadvantage index (CDI) for the U.S. Census tracts in which participants resided. Spearman's rank correlations were used to examine relationships, accounting for sex and race.
resultsCDI was not positively associated with inflammatory and metabolic markers of dysfunction. However, z_BMI (-0.234, P = 0.023), BF (-0.228, P = 0.028, n = 95), and VAT (-0.241, P = 0.042, n = 74) were significantly negatively associated with CDI. When stratifying by race, these relationships remained significant in Caucasian children only.
conclusionsThese findings suggest chronic stress during early childhood is not associated with inflammatory and metabolic biomarkers, typically observed in adults. Therefore, exposure to stress during this critical developmental period may remain latent and emerge during a later developmental stage.
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