ArticleScientific reports2016
PEGylated substrates of NSP4 protease: A tool to study protease specificity.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Building Blocks of 2,3-Diaminopropionic Acid Functionalized with an Oxa-Acid Spacer Shift the Functional Profile of Human Cathelicidin LL-37: Enhanced Enzymatic Stability and Selective Suppression of Neutrophil Degranulation.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Lipidated DAPEG Polymers as a Non-Toxic Transfection Agent-Influence of Fatty Acid Side Chain on Transfection Efficacy.Molecules (Basel, Switzerland) · 2025Article
- Polymers of functionalized diaminopropionic acid are efficient mediators of active exogenous enzyme delivery into cells.Scientific reports · 2024Article
- Brain-targeted intranasal delivery of protein-based gene therapy for treatment of ischemic stroke.Theranostics · 2024Article
- 5-Amino-3-methyl-Isoxazole-4-carboxylic Acid as a Novel Unnatural Amino Acid in the Solid Phase Synthesis of α/β-Mixed Peptides.Molecules (Basel, Switzerland) · 2022Article
- SP-1, a Serine Protease from the Gut Microbiota, Influences Colitis and Drives Intestinal Dysbiosis in Mice.Cells · 2021Article
- Novel Cell Permeable Polymers ofInternational journal of molecular sciences · 2021Article
- A Peptidomimetic Fluorescent Probe to Detect the Trypsin β2 Subunit of the Human 20S Proteasome.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herein we present the synthesis of a novel type of peptidomimetics composed of repeating diaminopropionic acid residues modified with structurally diverse heterobifunctional polyethylene glycol chains (abbreviated as DAPEG). Based on the developed compounds, a library of fluorogenic substrates was synthesized. Further library deconvolution towards human neutrophil serine protease 4 (NSP4) yielded highly sensitive and selective internally quenched peptidomimetic substrates. In silico analysis of the obtained peptidomimetics revealed the presence of an interaction network with distant subsites located on the enzyme surface.
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