ArticleNature communications2016
Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 165 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
165 citing papers in PubMed, 6 syntheses or guidelines pooled it, 314 citations in OpenAlex.
- Epigenetic signatures relating to disease-associated genotypic burden in familial risk of bipolar disorder.Translational psychiatry · 2022Pooled it
- Longitudinal associations of DNA methylation and sleep in children: a meta-analysis.Clinical epigenetics · 2022Pooled it
- Pooled it
- Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways.Nature genetics · 2019Pooled it
- Meta-analysis of transcriptomic datasets identifies genes enriched in the mammalian circadian pacemaker.Nucleic acids research · 2017Pooled it
- Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis.Oncotarget · 2017Pooled it
- Aberrant DNA methylation within circadian entrainment and clock genes two years after pediatric critical illness is associated with impaired physical and neurocognitive development.Clinical epigenetics · 2025Trial
- Rare Coding Variants Reveal Distinct Genetic Architectures Across Multidimensional Sleep Phenotypes.medRxiv : the preprint server for health sciences · 2026Article
- Multi-organ imaging and genetics show the impact of sleep patterns on the human brain and body.Communications medicine · 2026Article
- Chrononutrition-based dietary strategies for effective weight loss.European journal of clinical nutrition · 2026Article
- Circadian rhythms regulate refractive development across species.bioRxiv : the preprint server for biology · 2026Article
- Genetic and epigenetic insights into perioperative neurocognitive disorders: a narrative review.British journal of anaesthesia · 2026Review
- Genetic architecture of sleep in a genome wide association study of device measured sleep traits.Nature communications · 2026Article
- Assessing the causal impact of leisure-time physical activity and screen time on lifespan: a Mendelian randomization study.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026Article
- CircadianiScience · 2026Article
- Circadian irregularity in schizophrenia and familial risk: a comparative study.BMC psychiatry · 2026Article
- Morning Larks and Night Owls: Considering Chronotype in Evaluation of Patients with Pulmonary Hypertension.Annals of the American Thoracic Society · 2026Article
- Afternoon exercise was associated with greater fat loss than morning exercise in overweight/obese adults: an exploratory study of PER3 rs228697 genotype matching.Frontiers in physiology · 2026Article
- Association of CLOCK rs1801260 Polymorphism with Sleep Quality in Residents of the Far North.Bulletin of experimental biology and medicine · 2026Article
- The Modifying Role of Cortisol in the Sex-Specific Associations of Social Jetlag with Neurobehavioral Problems Among Adolescents: The Shanghai Adolescent Cohort Study.Nature and science of sleep · 2026Article
105 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 3 countries.
Funding
Abstract
Our sleep timing preference, or chronotype, is a manifestation of our internal biological clock. Variation in chronotype has been linked to sleep disorders, cognitive and physical performance, and chronic disease. Here we perform a genome-wide association study of self-reported chronotype within the UK Biobank cohort (n=100,420). We identify 12 new genetic loci that implicate known components of the circadian clock machinery and point to previously unstudied genetic variants and candidate genes that might modulate core circadian rhythms or light-sensing pathways. Pathway analyses highlight central nervous and ocular systems and fear-response-related processes. Genetic correlation analysis suggests chronotype shares underlying genetic pathways with schizophrenia, educational attainment and possibly BMI. Further, Mendelian randomization suggests that evening chronotype relates to higher educational attainment. These results not only expand our knowledge of the circadian system in humans but also expose the influence of circadian characteristics over human health and life-history variables such as educational attainment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.