Evidence map›Paper›PMID 26955814›Full record

Observational studyCardiovascular ultrasound2016

Left ventricular twist mechanics and its relation with aortic stiffness in chronic kidney disease patients without overt cardiovascular disease.

Samir Sulemane, Vasileios F Panoulas, Klio Konstantinou, Athanasios Bratsas, Frederick W Tam, Edwina A Brown, Petros Nihoyannopoulos

Erratum issuedOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cardiovascular ultrasound, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Samir SulemaneImperial College London, National Heart and Lung Institute, Sydney Street, SW6 3NP, London, UK. s.sulemane11@imperial.ac.uk.
Vasileios F PanoulasImperial College Healthcare NHS, Hammersmith Hospital, Ducane road, W12 0HP, London, UK.
Klio KonstantinouImperial College Healthcare NHS, Hammersmith Hospital, Ducane road, W12 0HP, London, UK.
Athanasios BratsasImperial College Healthcare NHS, Hammersmith Hospital, Ducane road, W12 0HP, London, UK.
Frederick W TamImperial College Renal and Transplant Centre, Hammersmith Hospital, Ducane road, W12 0HP, London, UK.
Edwina A BrownImperial College Renal and Transplant Centre, Hammersmith Hospital, Ducane road, W12 0HP, London, UK.
Petros NihoyannopoulosImperial College London, National Heart and Lung Institute, Sydney Street, SW6 3NP, London, UK.
Hammersmith Hospital · GBImperial College Healthcare NHS Trust · GBImperial College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent studies hypothesized left ventricular (LV) twist as a potential biomarker for evaluation of sub clinical myocardial disease, however its relationship with aortic stiffness has yet to be investigated. Chronic kidney disease (CKD) has been identified as a risk factor for both myocardial and arterial disease. As such we sought to explore the relationship between aortic stiffness and LV twist in CKD patients without known cardiovascular disease (CVD).

methodsIn this prospective, observational study we enrolled 106 CKD patients (Stages 1 to 5) with normal LVEF as assessed by conventional echocardiography. Aortic stiffness was measured using aortic pulse wave velocity (aPWV). We defined increased aPWV as ≥10 m/s. LV Twist was measured using two-dimensional speckle tracking echocardiography.

resultsPatients with increased aPWV had higher LV twist (p = 0.002) but similar LVEF (p = 0.486). Aortic PWV correlated crudely with age (p < 0.001), the presence of diabetes (p < 0.001), hypertension (p < 0.001), eGFR (p < 0.001), LVMI (p = 0.01), e/e' (p < 0.001) and LV twist (p = 0.003). In multivariable analyses after adjusting for age, gender, cardiovascular risk factors and hypertensive medication, aPWV was independently associated with LV twist (β = 0.163, p = 0.025).

conclusionsAortic stiffness independently associates with LV Twist in asymptomatic CKD patients. These findings suggest a close interaction between LV twist mechanics and arterial remodeling even before CVD becomes clinically relevant.

Indexed as

AortaAsymptomatic DiseasesEchocardiographyElastic ModulusFemaleHeart VentriclesHumansImage Interpretation, Computer-AssistedMaleMiddle AgedRenal Insufficiency, ChronicReproducibility of ResultsSensitivity and SpecificityVentricular Dysfunction, Left

Identifiers

PMID26955814
PMCPMC4784431
OpenAlexW4248442301

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.