ArticlePregnancy hypertension2016
Mid-pregnancy circulating immune biomarkers in women with preeclampsia and normotensive controls.
Article in Pregnancy hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Preeclamptic Women Have Decreased Circulating IL-10 (Interleukin-10) Values at the Time of Preeclampsia Diagnosis: Systematic Review and Meta-Analysis.Hypertension (Dallas, Tex. : 1979) · 2020Pooled it
- Association of Periconceptional Dietary Inflammatory Index and Hypertensive Disorders of Pregnancy and Its Subtype.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Observational
- Alarmins and their pivotal role in the pathogenesis of spontaneous abortion: insights for therapeutic intervention.European journal of medical research · 2024Review
- Immune checkpoint molecules B7-1 and B7-H1 as predictive markers of pre-eclampsia: A case-control study in a Ghana.Immunity, inflammation and disease · 2024Article
- Inflammatory markers are elevated in early pregnancy, but not late pregnancy, in women with overweight and obesity that later develop preeclampsia.American journal of reproductive immunology (New York, N.Y. : 1989) · 2023Article
- Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective Study.Molecules (Basel, Switzerland) · 2022Article
- Interferon epsilon and preterm birth subtypes; a new piece of the type I interferon puzzle during pregnancy?American journal of reproductive immunology (New York, N.Y. : 1989) · 2022Article
- A Systematic Review of the Safety of Blocking the IL-1 System in Human Pregnancy.Journal of clinical medicine · 2021Review
- Association ofAnimals : an open access journal from MDPI · 2021Article
- Maternal Serum Cytokine Concentrations in Healthy Pregnancy and Preeclampsia.Journal of pregnancy · 2021Review
- Quantitative ferumoxytol-enhanced MRI in pregnancy: A feasibility study in the nonhuman primate.Magnetic resonance imaging · 2020Article
- Association of pro- and anti-inflammatory cytokines in preeclampsia.Journal of clinical laboratory analysis · 2019Article
- Activation of a TLR9 mediated innate immune response in preeclampsia.Scientific reports · 2019Article
- Gene-Centric Analysis of Preeclampsia Identifies Maternal Association atHypertension (Dallas, Tex. : 1979) · 2018Article
- The Role of Interleukin-10 in the Pathophysiology of Preeclampsia.Current hypertension reports · 2018Review
- The impact of female fetal sex on preeclampsia and the maternal immune milieu.Pregnancy hypertension · 2018Article
- Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome.Endocrinology · 2018Article
- Repeated measures of inflammation and oxidative stress biomarkers in preeclamptic and normotensive pregnancies.American journal of obstetrics and gynecology · 2017Article
- Effects of maternal obesity on placental function and fetal development.Reproduction (Cambridge, England) · 2017Review
- Influence of vaginal lactoferrin administration on amniotic fluid cytokines and its role against inflammatory complications of pregnancy.Journal of inflammation (London, England) · 2017Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
objectivesTo determine if mid-pregnancy circulating immune biomarkers are associated with preeclampsia. STUDY
designNested case-control study of 410 preeclamptic women and 297 normotensive controls with primiparous singleton pregnancies enrolled in the Danish National Birth Cohort. The mean gestational age in our cohort is 16 weeks (range 9-26).
main outcome measuresPreeclampsia was defined by blood pressure ⩾140/90 mmHg and proteinuria ⩾3 g/24 h. Serum immune biomarkers included interleukin (IL)-6, IL-6 receptor, IL-4, IL-4 receptor, IL-5, IL-12, IL-2, TNF-α, TNF-β, TNF-receptor, IL-1β, IL-1α, IL-8, IL-10, IFN-γ, IL-18, macrophage migration inhibitory factor, macrophage inflammatory protein, transforming growth factor-beta (TGF-β), and RANTES. Associations with preeclampsia, term preeclampsia and preterm preeclampsia were determined using two logistic regression models; (1) biomarkers were dichotomized by the limit of detection (LOD); (2) on the continuous scale, non-detectable values were imputed by LOD/2 and transformed (base 2). All models were adjusted for body mass index and smoking.
resultsIL1β was significantly associated with a decrease in the log odds of preeclampsia (p=0.0065), term preeclampsia (p=0.0230) and preterm preeclampsia (p=0.0068). Results were similar for IL4r and preeclampsia (p=0.0383). In the dichotomized models, detectable TNF-β was significantly associated with preeclampsia (ORadj 1.6, 95% CI 1.1-2.3) and term preeclampsia (OR 1.7, 95% CI 1.1-2.5) but not preterm preeclampsia. Detectable IL6 was significantly with term preeclampsia only (OR 1.5, 95% CI 1.1-2.2).
conclusionMid-pregnancy circulating IL1β, IL4r, IL6, and TNFβ were associated with preeclampsia. However, results were not consistent across statistical models. As the relationship is complex, future studies should explore cytokine clusters in preeclampsia risk.
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