Evidence map›Paper›PMID 26955633›Full record

ArticleFrontiers in cardiovascular medicine2016

Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome.

Patrycja A Naesgaard, Ricardo A León de la Fuente, Stein Tore Nilsen, Volker Pönitz, Trygve Brügger-Andersen, Heidi Grundt, Harry Staines, Dennis W T Nilsen

Open access · goldAbstract read
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Article in Frontiers in cardiovascular medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Patrycja A NaesgaardDepartment of Cardiology, Stavanger University Hospital, Stavanger, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway.
Ricardo A León de la FuenteDepartment of Cardiology, Stavanger University Hospital, Stavanger, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway; Cardiology Research Institute, Catholic University of Salta, Salta, Argentina.
Stein Tore NilsenDepartment of Research, Stavanger University Hospital, Stavanger, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Volker PönitzDepartment of Cardiology, Stavanger University Hospital , Stavanger , Norway.
Trygve Brügger-AndersenDepartment of Cardiology, Stavanger University Hospital , Stavanger , Norway.
Heidi GrundtDepartment of Clinical Science, University of Bergen, Bergen, Norway; Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway.
Harry StainesSigma Statistical Services , Balmullo , UK.
Dennis W T NilsenDepartment of Cardiology, Stavanger University Hospital, Stavanger, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway.
Stavanger University Hospital · NORoyal Statistical Society · GBUniversity of Bergen · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral studies have demonstrated an association between low vitamin D levels and cardiovascular risk. Vitamin D cut-off levels are still under debate.

objectivesTo assess two cut-off levels, 40 and 70 nmol/L, respectively, for vitamin D measured as 25-hydroxyvitamin D in chest pain patients with suspected acute coronary syndrome.

methodsWe investigated 1853 patients from coastal-Norway and inland Northern-Argentina. A similar database was used for pooling of data. Two-year follow-up data including all-cause mortality, cardiac death, and sudden cardiac death in the total patient population were analyzed, applying univariate and multivariable analysis.

resultsTwo hundred fifty-five patients with known vitamin D concentrations died. In the multivariable analysis, there was a decrease in total mortality above a cut-off level of 40 nmol/L and a decrease in cardiac death above a cut-off level of 70 nmol/L [HRs of 0.66 (95% CI, 0.50-0.88), p = 0.004 and 0.46 (95% CI, 0.22-0.94), p = 0.034, respectively].

conclusionVitamin D cut-off levels of 40 and 70 nmol/L were related to total mortality and cardiac death, respectively.

Indexed as

acute coronary syndromecardiac deathcut-off levelstotal mortalityvitamin Dvitamin D deficiency

Identifiers

PMID26955633
PMCPMC4767896
OpenAlexW2302019951

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.