ArticleNeuroImage. Clinical2016
Alpha desynchronization and fronto-parietal connectivity during spatial working memory encoding deficits in ADHD: A simultaneous EEG-fMRI study.
Article in NeuroImage. Clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Event-related brain oscillations in attention-deficit/hyperactivity disorder (ADHD): A systematic review and meta-analysis.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2022Pooled it
- Electrophysiological and Clinical Predictors of Methylphenidate, Guanfacine, and Combined Treatment Outcomes in Children With Attention-Deficit/Hyperactivity Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Trial
- Methylphenidate, Guanfacine, and Combined Treatment Effects on Electroencephalography Correlates of Spatial Working Memory in Attention-Deficit/Hyperactivity Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Trial
- Attention in laboratory tasks versus naturalistic learning contexts: Heterogeneity in measurement and mechanisms.Research square · 2026Article
- Structural integrity of the anterior thalamic radiation predicts alpha oscillations and inattention during visual encoding.Scientific reports · 2026Article
- A rest-task fMRI study of spatial working memory in HIV-infected individuals across cognitive states.BMC medical imaging · 2026Article
- Review
- An explainable machine learning model based on multidimensional task-state electroencephalography for identifying attention-deficit/hyperactivity disorder comorbid developmental dyslexia.Frontiers in human neuroscience · 2026Article
- EEG-Based Prediction of Stress Responses to Naturalistic Decision-Making Stimuli in Police Cadets.Sensors (Basel, Switzerland) · 2025Article
- Mobile EEG examination of putative biomarkers of mental health in individuals that use cannabis.NPP - digital psychiatry and neuroscience · 2025Article
- Alpha event-related decreases during encoding in adults with ADHD - An investigation of sustained attention and working memory processes.Behavioural brain research · 2024Article
- Application status and prospects of multimodal EEG-fMRI in HIV-associated neurocognitive disorders.Frontiers in neurology · 2024Review
- Translating Decades of Neuroscience Research into Diagnostic and Treatment Biomarkers for ADHD.Advances in neurobiology · 2024Review
- Neuronal Hyperactivation in EEG Data during Cognitive Tasks Is Related to the Apolipoprotein J/Clusterin Genotype in Nondemented Adults.International journal of molecular sciences · 2023Article
- Relating neural oscillations to laminar fMRI connectivity in visual cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Readiness to remember: predicting variability in episodic memory.Trends in cognitive sciences · 2022Review
- EEG Data Quality in Real-World Settings: Examining Neural Correlates of Attention in School-Aged Children.Mind, brain and education : the official journal of the International Mind, Brain, and Education Society · 2022Article
- The relationship of muscular endurance and coordination and dexterity with behavioral and neuroelectric indices of attention in preschool children.Scientific reports · 2022Article
- Effects of facial expression and gaze interaction on brain dynamics during a working memory task in preschool children.PloS one · 2022Article
- Effects of context on the neural correlates of attention in a college classroom.NPJ science of learning · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The underlying mechanisms of alpha band (8-12 Hz) neural oscillations are of importance to the functioning of attention control systems as well as to neuropsychiatric conditions that are characterized by deficits of that system, such as attention deficit hyperactivity disorder (ADHD). The objectives of the present study were to test if visual encoding-related alpha event-related desynchronization (ERD) correlates with fronto-parieto-occipital connectivity, and whether this is disrupted in ADHD during spatial working memory (SWM) performance. We acquired EEG concurrently with fMRI in thirty boys (12-16 yrs. old, 15 with ADHD), during SWM encoding. Psychophysiological connectivity analyses indicated that alpha ERD during SWM encoding was associated with both occipital activation and fronto-parieto-occipital functional connectivity, a finding that expands on prior associations between alpha ERD and occipital activation. This finding provides novel support for the interpretation of alpha ERD (and the associated changes in occipital activation) as a phenomenon that involves, and perhaps arises as a result of, top-down network interactions. Alpha ERD was associated less strongly with occipital activity, but associated more strongly with fronto-parieto-occipital connectivity in ADHD, consistent with a compensatory attentional response. Additionally, we illustrate that degradation of EEG data quality by MRI-amplified motion artifacts is robust to existing cleaning algorithms and is significantly correlated with hyperactivity symptoms and the ADHD Combined Type diagnosis. We conclude that persistent motion-related MR artifacts in EEG data can increase variance and introduce bias in interpretation of group differences in populations characterized by hypermobility--a clear limitation of current-state EEG-fMRI methodology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.