ArticleNeuroImage. Clinical2016
Characterizing "fibrofog": Subjective appraisal, objective performance, and task-related brain activity during a working memory task.
Article in NeuroImage. Clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
- Subjective cognitive complaints in patients with stress-related exhaustion disorder: a cross sectional study.BMC psychology · 2021Trial
- Salivary cortisol is associated with cognitive changes in patients with fibromyalgia.Scientific reports · 2021Trial
- Connectivity differences between Gulf War Illness (GWI) phenotypes during a test of attention.PloS one · 2019Trial
- The Effect of Metacognitive and Emotional Schemas on the Severity of Symptoms in Patients with Fibromyalgia.Diagnostics (Basel, Switzerland) · 2026Article
- [Long-standing myalgia and hypouricemia in a young woman : Case report and review of the literature].Zeitschrift fur Rheumatologie · 2025Review
- Planning and Problem-Solving Impairments in Fibromyalgia: The Predictive Role of Updating, Inhibition, and Mental Flexibility.Journal of clinical medicine · 2025Article
- Healing synchrony? potential benefits of interpersonal synchrony for chronic pain management.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Reaction Time in Fibromyalgia Patients.Current rheumatology reviews · 2024Article
- Atrophy patterns in hippocampal subregions and their relationship with cognitive function in fibromyalgia patients with mild cognitive impairment.Frontiers in neuroscience · 2024Article
- Mind the Mood: Momentary Depression and Anxiety Moderate the Correspondence Between Subjective and Objective Cognitive Functioning in Fibromyalgia.Arthritis care & research · 2023Article
- Objective cognitive functioning in patients with stress-related disorders: a cross-sectional study using remote digital cognitive testing.BMC psychiatry · 2023Article
- Novel Approaches in Molecular Imaging and Neuroimaging of Fibromyalgia.International journal of molecular sciences · 2022Review
- The effect of home-based transcranial direct current stimulation in cognitive performance in fibromyalgia: A randomized, double-blind sham-controlled trial.Frontiers in human neuroscience · 2022Article
- Characterizing Neurocognitive Impairment in Juvenile Fibromyalgia Syndrome: Subjective and Objective Measures of Dyscognition.Frontiers in pediatrics · 2022Article
- Article
- Subjective Cognitive Functioning in Silicone Breast Implant Patients: A Cohort Study.Plastic and reconstructive surgery. Global open · 2021Article
- Working Memory Performance, Pain and Associated Clinical Variables in Women With Fibromyalgia.Frontiers in psychology · 2021Article
- Fibrofog in Daily Life: An Examination of Ambulatory Subjective and Objective Cognitive Function in Fibromyalgia.Arthritis care & research · 2020Article
- Metabolomic Differentials in Women With and Without Fibromyalgia.Clinical and translational science · 2020Article
- Exercise challenge alters Default Mode Network dynamics in Gulf War Illness.BMC neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
The subjective experience of cognitive dysfunction ("fibrofog") is common in fibromyalgia. This study investigated the relation between subjective appraisal of cognitive function, objective cognitive task performance, and brain activity during a cognitive task using functional magnetic resonance imaging (fMRI). Sixteen fibromyalgia patients and 13 healthy pain-free controls completed a battery of questionnaires, including the Multiple Ability Self-Report Questionnaire (MASQ), a measure of self-perceived cognitive difficulties. Participants were evaluated for working memory performance using a modified N-back working memory task while undergoing Blood Oxygen Level Dependent (BOLD) fMRI measurements. Fibromyalgia patients and controls did not differ in working memory performance. Subjective appraisal of cognitive function was associated with better performance (accuracy) on the working memory task in healthy controls but not in fibromyalgia patients. In fibromyalgia patients, increased perceived cognitive difficulty was positively correlated with the severity of their symptoms. BOLD response during the working memory task did not differ between the groups. BOLD response correlated with task accuracy in control subjects but not in fibromyalgia patients. Increased subjective cognitive impairment correlated with decreased BOLD response in both groups but in different anatomic regions. In conclusion, "fibrofog" appears to be better characterized by subjective rather than objective impairment. Neurologic correlates of this subjective experience of impairment might be separate from those involved in the performance of cognitive tasks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.