ArticleCase reports in gastrointestinal medicine2016
Mixed Adenoneuroendocrine Carcinoma Is a Rare but Important Tumour Found in the Oesophagus.
Article in Case reports in gastrointestinal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Insights into gastric mixed adenoneuroendocrine carcinoma: a novel comparative study of clinicopathological features and survival outcomes.Frontiers in endocrinology · 2025Article
- Metastatic Mixed Adeno-Neuroendocrine Carcinoma of the Colon to the Liver with Multiple Peritoneal Deposits: A Case Report.The American journal of case reports · 2021Article
- Mixed adenoneuroendocrine carcinoma of the liver: A rare case report.Molecular and clinical oncology · 2020Article
- Neuroendocrine carcinoma of the esophagus with an adenocarcinoma component.Clinical journal of gastroenterology · 2019Article
- A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett's esophagus: literature and review.Surgical case reports · 2018Article
- Two patients with rare mixed adenoneuroendocrine carcinomas of the rectum.SAGE open medical case reports · 2018Article
- Mixed Adenoneuroendocrine Carcinoma of the Esophagus: A Case Report and Review of the Literature.Nigerian journal of surgery : official publication of the Nigerian Surgical Research SocietyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumour of the gastrointestinal tract that consists of a dual adenocarcinomatous and neuroendocrine differentiation, each component representing at least 30% of the tumour. We report a case of a 68-year-old man who presented with two-month history of postprandial pain and vomiting. Gastric endoscopy revealed a polypoid mass in the lower part of the oesophagus. In contrast to the majority of these tumours, this biopsy was immunohistochemically positive for chromogranin A, and synaptophysin and Ki-67 index was 50% and the tumour was diagnosed as poorly differentiated neuroendocrine carcinoma of the oesophagus. The patient underwent surgery and lower oesophagus resection was performed. Based on the histopathology and immunohistochemistry of the tumour in the oesophagogastrectomy specimen, a mixed adenoneuroendocrine carcinoma (MANEC) was diagnosed. The objective of this case report is to advocate for the focus on the MANEC diagnosis as such patients need to be referred to a centre of excellence with expertise in NET tumours, to have the correct diagnostic work-up, treatment, and secondary diagnostic procedures performed at progression, as this will have paramount influence of the choice of treatment.
Identifiers
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Registered trials
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