ArticleThe journal of physical chemistry. C, Nanomaterials and interfaces2015
Denoising Stimulated Raman Spectroscopic Images by Total Variation Minimization.
Article in The journal of physical chemistry. C, Nanomaterials and interfaces, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 46 citations in OpenAlex.
- AI-Assisted Coherent Raman Scattering Microscopy for Clinical Translation.Chemical & biomedical imaging · 2026Review
- Oleic acid fuels cisplatin-resistant ovarian cancer through FABP4-driven lipid uptake.Molecular metabolism · 2026Article
- Broadband Coherent Raman Scattering: Excitation Architectures and Operating Regimes.Molecules (Basel, Switzerland) · 2026Review
- Self-Supervised Elimination of Non-Independent Noise in Hyperspectral Imaging.Newton ((New York, N.Y.) · 2025Article
- Machine learning empowered coherent Raman imaging and analysis for biomedical applications.Communications engineering · 2025Review
- High-content stimulated Raman histology of human breast cancer.Theranostics · 2024Article
- Full-Spectrum CARS Microscopy of Cells and Tissues with Ultrashort White-Light Continuum Pulses.The journal of physical chemistry. B · 2023Article
- Visualizing the lipid dynamics role in infrared neural stimulation using stimulated Raman scattering.Biophysical journal · 2022Article
- Multiplex Stimulated Raman Scattering Imaging Cytometry Reveals Lipid-Rich Protrusions in Cancer Cells under Stress Condition.iScience · 2020Article
- Ultrafast chemical imaging by widefield photothermal sensing of infrared absorption.Science advances · 2019Article
- In Situ and In Vivo Molecular Analysis by Coherent Raman Scattering Microscopy.Annual review of analytical chemistry (Palo Alto, Calif.) · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
High-speed coherent Raman scattering imaging is opening a new avenue to unveiling the cellular machinery by visualizing the spatio-temporal dynamics of target molecules or intracellular organelles. By extracting signals from the laser at MHz modulation frequency, current stimulated Raman scattering (SRS) microscopy has reached shot noise limited detection sensitivity. The laser-based local oscillator in SRS microscopy not only generates high levels of signal, but also delivers a large shot noise which degrades image quality and spectral fidelity. Here, we demonstrate a denoising algorithm that removes the noise in both spatial and spectral domains by total variation minimization. The signal-to-noise ratio of SRS spectroscopic images was improved by up to 57 times for diluted dimethyl sulfoxide solutions and by 15 times for biological tissues. Weak Raman peaks of target molecules originally buried in the noise were unraveled. Coupling the denoising algorithm with multivariate curve resolution allowed discrimination of fat stores from protein-rich organelles in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.