Evidence map›Paper›PMID 26955397›Full record

ArticleNano today2015

Nanomedicines for Endothelial Disorders.

Bomy Lee Chung, Michael J Toth, Nazila Kamaly, Yoshitaka J Sei, Jacob Becraft, Willem J M Mulder, Zahi A Fayad, Omid C Farokhzad, YongTae Kim, Robert Langer

Open access · greenAbstract read
In one paragraph

Article in Nano today, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
  2. Cell-derived nanomaterials for biomedical applications.Science and technology of advanced materials · 2024
    Review
  3. Pathologically triggeredActa pharmaceutica Sinica. B · 2023
    Article
  4. Review
  5. Maedica · 2022
    Article
  6. Review
  7. Review
  8. Polymer nanomedicines.Advanced drug delivery reviews · 2020
    Review
  9. Review
  10. Article
  11. Article
  12. Nanomedicines for dysfunctional macrophage-associated diseases.Journal of controlled release : official journal of the Controlled Release Society · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Bomy Lee ChungDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Department of Chemical Engineering, Massachusetts Institute of Technology.
Michael J TothGeorge W. Woodruff School of Mechanical Engineering, Wallace H. Coulter Department of Biomedical Engineering, Institute for Electronics and Nanotechnology (IEN), Parker H. Petit Institute for Bioengineering and Bioscience (IBB), Georgia Institute of Technology.
Nazila KamalyDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Laboratory of Nanomedicine and Biomaterials, Brigham and Women's Hospital, Harvard Medical School.
Yoshitaka J SeiGeorge W. Woodruff School of Mechanical Engineering, Wallace H. Coulter Department of Biomedical Engineering, Institute for Electronics and Nanotechnology (IEN), Parker H. Petit Institute for Bioengineering and Bioscience (IBB), Georgia Institute of Technology.
Jacob BecraftDepartment of Biological Engineering, Massachusetts Institute of Technology.
Willem J M MulderTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai.
Zahi A FayadTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai.
Omid C FarokhzadLaboratory of Nanomedicine and Biomaterials, Brigham and Women's Hospital, Harvard Medical School; King Abdulaziz University, Jeddah, Saudi Arabia.
YongTae KimGeorge W. Woodruff School of Mechanical Engineering, Wallace H. Coulter Department of Biomedical Engineering, Institute for Electronics and Nanotechnology (IEN), Parker H. Petit Institute for Bioengineering and Bioscience (IBB), Georgia Institute of Technology.
Robert LangerDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Department of Chemical Engineering, Massachusetts Institute of Technology; Department of Biological Engineering, Massachusetts Institute of Technology; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology.
Georgia Institute of Technology · USImaging Center · USMassachusetts Institute of Technology · USParker Hannifin (United States) · USHarvard–MIT Division of Health Sciences and Technology · USHarvard University · US

Funding

The Development of Clinical Grade, Targeted Magnetic NanoparticlesU54CA151884 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2010 to 2014
$11.3M
Research Training Program Plan on Cell and Tissue Engineering (CTEng)T32GM008433 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GARCIA, ANDRES J · 1991 to 2021
$7.1M
Targeted delivery of a sonic hedgehog inhibitor for the study of medulloblastoma therapeuticsR21NS091682 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI KIM, YONGTAE · 2015 to 2016
$424k
NCI NIH HHS U54 CA151884NHLBI NIH HHS HHSN268201000045CNIGMS NIH HHS T32 GM008433NINDS NIH HHS R21 NS091682
6 · The paper itself

Abstract

The endothelium lines the internal surfaces of blood and lymphatic vessels and has a critical role in maintaining homeostasis. Endothelial dysfunction is involved in the pathology of many diseases and conditions, including disorders such as diabetes, cardiovascular diseases, and cancer. Given this common etiology in a range of diseases, medicines targeting an impaired endothelium can strengthen the arsenal of therapeutics. Nanomedicine - the application of nanotechnology to healthcare - presents novel opportunities and potential for the treatment of diseases associated with an impaired endothelium. This review discusses therapies currently available for the treatment of these disorders and highlights the application of nanomedicine for the therapy of these major disease complications.

Indexed as

atherosclerosiscancerdiabetesendothelial disorderendotheliumnanomedicinepermeability

Identifiers

PMID26955397
PMCPMC4778260
OpenAlexW2226125668

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.