ArticleDementia and geriatric cognitive disorders extra
The Influence of Patient Characteristics on Anticholinergic Events in Older People.
Article in Dementia and geriatric cognitive disorders extra. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between anticholinergic drug burden and mortality in older people: a systematic review.European journal of clinical pharmacology · 2020Pooled it
- Pooled it
- Anticholinergic medicines - medication management, prescribing cascades, and deprescribing.International journal of clinical pharmacy · 2025Article
- Clinical pharmacist-led assessment and management of anticholinergic burden and fall risk in geriatric patients.BMC geriatrics · 2023Article
- A Universal Pharmacological-Based List of Drugs with Anticholinergic Activity.Pharmaceutics · 2023Article
- Prevalence of anticholinergic burden and risk factors amongst the older population: analysis of insurance claims data of Korean patients.International journal of clinical pharmacy · 2020Article
- Are Anticholinergic Symptoms a Risk Factor for Falls in Older General Practice Patients With Polypharmacy? Study Protocol for the Development and Validation of a Prognostic Model.Frontiers in pharmacology · 2020Article
- Anticholinergic Prescribing in Medicare Part D Beneficiaries Residing in Nursing Homes: Results from a Retrospective Cross-Sectional Analysis of Medicare Data.Drugs & aging · 2017Article
- An overview of pharmacodynamic modelling, ligand-binding approach and its application in clinical practice.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2017Review
- Temporal trends in the use of antidiabetic medicines: a nationwide 9-year study in older people living in New Zealand.Therapeutic advances in drug safety · 2016Article
- Examination and Estimation of Anticholinergic Burden: Current Trends and Implications for Future Research.Drugs & aging · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo examine patient characteristics that predict adverse anticholinergic-type events in older people.
methodsThis retrospective population-level study included 2,248 hospitalised patients. Individual data on medicines that are commonly associated with anticholinergic events (delirium, constipation and urinary retention) were identified. Patient characteristics examined were medicines with anticholinergic effects (ACh burden), age, sex, non-anticholinergic medicines (non-ACM), Charlson comorbidity index scores and ethnicity. The Akaike information criterion was used for model selection. The data were analysed using logistic regression models for anticholinergic events using the software NONMEM.
resultsACh burden was found to be a significant independent predictor for developing an anticholinergic event [adjusted odds ratio (aOR): 3.21, 95% CI: 1.23-5.81] for those taking an average of 5 anticholinergic medicines compared to those taking 1. Both non-ACM and age were also independent risk factors (aOR: 1.41, 95% CI: 1.31-1.51 and aOR: 1.08, 95% CI: 1.05-1.10, respectively).
conclusionTo our knowledge, this is the first study that has examined population-level data in a nonlinear model framework to predict anticholinergic-type adverse events. This study evaluated the relationship between important patient characteristics and the occurrence of anticholinergic-type events. These findings reinforce the clinical significance of reviewing anticholinergic medicines in older people.
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