ArticleFrontiers in plant science2016
The Dynamic Changes of the Plasma Membrane Proteins and the Protective Roles of Nitric Oxide in Rice Subjected to Heavy Metal Cadmium Stress.
Article in Frontiers in plant science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 88 citations in OpenAlex.
- Multiomics Insights in Research of Nitric Oxide (NO) Donors in Plants upon Stress.International journal of molecular sciences · 2026Review
- Article
- Genome-wide analysis of Phaseolus vulgaris L. miR172 gene family members under heavy metal stress.BMC genomics · 2026Article
- Modulatory role of nitric oxide in cobalt-induced stress in two lettuce (Frontiers in plant science · 2026Article
- Article
- Cadmium Contamination in Asian Rice (Plants (Basel, Switzerland) · 2025Review
- Nitric oxide in plants: an insight on redox activity and responses toward abiotic stress signaling.Plant signaling & behavior · 2024Review
- Selenium-Binding Protein 1 (SBP1): A New Putative Player of Stress Sensing in Plants.International journal of molecular sciences · 2024Review
- Review
- Reactive oxygen species- and nitric oxide-dependent regulation of ion and metal homeostasis in plants.Journal of experimental botany · 2023Article
- Involvement of NO in V-ATPase Regulation in Cucumber Roots under Control and Cadmium Stress Conditions.Plants (Basel, Switzerland) · 2023Article
- Assessment of Shoot Priming Efficiency to Counteract Complex Metal Stress in HalotolerantPlants (Basel, Switzerland) · 2023Article
- Sodium Nitroprusside Improves Bamboo Resistance under Mn and Cr Toxicity with Stimulation of Antioxidants Activity, Relative Water Content, and Metal Translocation and Accumulation.International journal of molecular sciences · 2023Article
- Proteomic and physiological analyses to elucidate nitric oxide-mediated adaptive responses of barley under cadmium stress.Physiology and molecular biology of plants : an international journal of functional plant biology · 2022Article
- The Role of Nitric Oxide Signaling in Plant Responses to Cadmium Stress.International journal of molecular sciences · 2022Review
- Priming Strategies for Benefiting Plant Performance under Toxic Trace Metal Exposure.Plants (Basel, Switzerland) · 2021Review
- Knockout ofGenes · 2020Article
- Differential expression pattern of the proteome in response to cadmium stress based on proteomics analysis of wheat roots.BMC genomics · 2020Article
- Deepening the knowledge on the removal of Cr(VI) by L. minuta Kunth: removal efficiency and mechanisms, lipid signaling pathways, antioxidant response, and toxic effects.Environmental science and pollution research international · 2020Article
- Changes in sucrose metabolism in maize varieties with different cadmium sensitivities under cadmium stress.PloS one · 2020Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The heavy metal cadmium is a common environmental contaminant in soils and has adverse effects on crop growth and development. The signaling processes in plants that initiate cellular responses to environmental stress have been shown to be located in the plasma membrane (PM). A better understanding of the PM proteome in response to environmental stress might provide new insights for improving stress-tolerant crops. Nitric oxide (NO) is reported to be involved in the plant response to cadmium (Cd) stress. To further investigate how NO modulates protein changes in the plasma membrane during Cd stress, a quantitative proteomics approach based on isobaric tags for relative and absolute quantification (iTRAQ) was used to identify differentially regulated proteins from the rice plasma membrane after Cd or Cd and NO treatment. Sixty-six differentially expressed proteins were identified, of which, many function as transporters, ATPases, kinases, metabolic enzymes, phosphatases, and phospholipases. Among these, the abundance of phospholipase D (PLD) was altered substantially after the treatment of Cd or Cd and NO. Transient expression of the PLD fused with green fluorescent peptide (GFP) in rice protoplasts showed that the Cd and NO treatment promoted the accumulation of PLD in the plasma membrane. Addition of NO also enhanced Cd-induced PLD activity and the accumulation of phosphatidic acid (PA) produced through PLD activity. Meanwhile, NO elevated the activities of antioxidant enzymes and caused the accumulation of glutathione, both which function to reduce Cd-induced H2O2 accumulation. Taken together, we suggest that NO signaling is associated with the accumulation of antioxidant enzymes, glutathione and PA which increases cadmium tolerance in rice via the antioxidant defense system.
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