ArticleAdvanced functional materials2015
Mechanically Tunable Hollow Silica Ultrathin Nanoshells for Ultrasound Contrast Agents.
Article in Advanced functional materials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Real-time color flow mapping of ultrasound microrobots.Science advances · 2025Article
- Micro/nanosystems for controllable drug delivery to the brain.Innovation (Cambridge (Mass.)) · 2024Review
- Medical Imaging Technology for Micro/Nanorobots.Nanomaterials (Basel, Switzerland) · 2023Review
- A Novel Platform of MOF for Sonodynamic Therapy Advanced Therapies.Pharmaceutics · 2023Review
- Ultrasound contrast agents from microbubbles to biogenic gas vesicles.Medical review (2021) · 2023Review
- Dual-Mode Fluorescence/Ultrasound Imaging with Biocompatible Metal-Doped Graphene Quantum Dots.ACS biomaterials science & engineering · 2022Article
- Emerging photodynamic/sonodynamic therapies for urological cancers: progress and challenges.Journal of nanobiotechnology · 2022Review
- Acoustics at the nanoscale (nanoacoustics): A comprehensive literature review.: Part II: Nanoacoustics for biomedical imaging and therapy.Sensors and actuators. A, Physical · 2021Article
- Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications.Beilstein journal of nanotechnology · 2021Review
- Accurately Controlled Delivery of Temozolomide by Biocompatible UiO-66-NHInternational journal of nanomedicine · 2021Article
- Hollow Silica Particles: Recent Progress and Future Perspectives.Nanomaterials (Basel, Switzerland) · 2020Review
- Indocyanine green modified silica shells for colon tumor marking.Applied surface science · 2020Article
- Increased Survival by Pulmonary Treatment of Established Lung Metastases with Dual STAT3/CXCR4 Inhibition by siRNA Nanoemulsions.Molecular therapy : the journal of the American Society of Gene Therapy · 2019Article
- Directional coupling in spatially distributed nanoreactors.RSC advances · 2019Article
- Thickness and Sphericity Control of Hollow Hard Silica Shells through Iron (III) Doping: Low Threshold Ultrasound Contrast Agents.Advanced functional materials · 2019Article
- Tuning the ultrasonic and photoacoustic response of polydopamine-stabilized perfluorocarbon contrast agents.Journal of materials chemistry. B · 2019Article
- MRI-guided transurethral insonation of silica-shell phase-shift emulsions in the prostate with an advanced navigation platform.Medical physics · 2019Article
- Doppler Ultrasound-Visible SignalMark Microspheres are Better Identified than HydroMARKAnnals of surgical oncology · 2018Article
- Ultrasound-guided intertumoral injection of contrast agents combined with human p53 gene for the treatment of breast cancer.The Kaohsiung journal of medical sciences · 2018Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Perfluoropentane (PFP) gas filled biodegradable iron-doped silica nanoshells have been demonstrated as long-lived ultrasound contrast agents. Nanoshells are synthesized by a sol-gel process with tetramethyl orthosilicate (TMOS) and iron ethoxide. Substituting a fraction of the TMOS with R-substituted trialkoxysilanes produces ultrathin nanoshells with varying shell thicknesses and morphologies composed of fused nanoflakes. The ultrathin nanoshells had continuous ultrasound Doppler imaging lifetimes exceeding 3 hours, were twice as bright using contrast specific imaging, and had decreased pressure thresholds compared to control nanoshells synthesized with just TMOS. Transmission electron microscopy (TEM) showed that the R-group substituted trialkoxysilanes could reduce the mechanically critical nanoshell layer to 1.4 nm. These ultrathin nanoshells have the mechanical behavior of weakly linked nanoflakes but the chemical stability of silica. The synthesis can be adapted for general fabrication of three-dimensional nanostructures composed of nanoflakes, which have thicknesses from 1.4-3.8 nm and diameters from 2-23 nm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.