ReviewAdolescent health, medicine and therapeutics2016
The epidemiology of acne vulgaris in late adolescence.
Review in Adolescent health, medicine and therapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04213638 (Randomized Controlled Trial of Single Microneedle Radiofrequency for Moderate-to-Severe Acne Vulgaris), which is not on this map. Cited by 138 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Controlled Trial of Single Microneedle Radiofrequency for Moderate-to-Severe Acne Vulgaris
Who cites it
138 citing papers in PubMed, 9 syntheses or guidelines pooled it, 317 citations in OpenAlex.
- Efficacy and Safety of Er:Glass versus COAesthetic plastic surgery · 2026Pooled it
- Oral Probiotics inMedicina (Kaunas, Lithuania) · 2025Pooled it
- Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women.Clinical endocrinology · 2025Guideline
- Topical, light-based, and complementary interventions for acne: an overview of systematic reviews.The Cochrane database of systematic reviews · 2024Pooled it
- Efficacy and Safety of Transplantation of Autologous Fat, Platelet-Rich Plasma (PRP) and Stromal Vascular Fraction (SVF) in the Treatment of Acne Scar: Systematic Review and Meta-analysis.Aesthetic plastic surgery · 2023Pooled it
- A meta-analysis of fractional COLasers in medical science · 2021Pooled it
- Systematic review of the epidemiology of acne vulgaris.Scientific reports · 2020Pooled it
- External Application of Herbal Medicines for Acne Vulgaris: A Systematic Review and Meta Analysis.Journal of pharmacopuncture · 2020Pooled it
- Pooled it
- Fractional CO2 laser with topical insulin versus PRP for atrophic acne scars: a randomized split-face study.Archives of dermatological research · 2025Trial
- Clinical and cost-effectiveness of spironolactone in treating persistent facial acne in women: SAFA double-blinded RCT.Health technology assessment (Winchester, England) · 2024Trial
- Efficacy and safety of N-acetyl-GED-0507-34-LEVO gel in patients with moderate-to severe facial acne vulgaris: a phase IIb randomized double-blind, vehicle-controlled trial.The British journal of dermatology · 2022Trial
- Clinical evaluation of efficacy of intralesional platelet-rich plasma injection versus 1064 nm long-pulsed Neodymium:YAG laser in the treatment of inflammatory acne vulgaris in adolescent and post-adolescent patients: a prospective randomized split-face comparative study.Lasers in medical science · 2022Trial
- Efficacy and Safety of Topical Clascoterone Cream, 1%, for Treatment in Patients With Facial Acne: Two Phase 3 Randomized Clinical Trials.JAMA dermatology · 2020Trial
- Skin Health Literacy in Ontario Secondary Schools: An Overlooked Opportunity for Preventive Health Education.The Journal of school health · 2026Article
- Long-Term or Recurrent Antibiotic Use During Childhood or Adolescence and the Risk of Kidney Cancer: A Cohort Study.Cancer medicine · 2026Article
- Prevalence and antibiotic resistance pattern of Staphylococcus spp. isolated from acne, and disrupting their antimicrobial resistance: unveiling the potential of Ganoderma lucidum extract.Journal, genetic engineering & biotechnology · 2026Article
- Spironolactone for the treatment of acne vulgaris affecting female patients aged ≤ 18 years: results from a UK and Irish Survey of healthcare professionals.Skin health and disease · 2026Article
- Adverse Events Associated with Clascoterone: A Real-World Pharmacovigilance Study of the Food and Drug Administration Adverse Event Reporting System.Therapeutic innovation & regulatory science · 2026Article
- Comparative efficacy and skin barrier effects of topical dapsone and benzoyl peroxide in acne vulgaris.International journal of women's dermatology · 2026Article
78 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
importanceAcne vulgaris is the most common skin condition affecting late adolescents across the globe. Although prior studies have evaluated epidemiologic patterns of acne vulgaris in various ethnicities and regions, adequate understanding of the worldwide burden of the disease associated with patients in their late adolescence (15-19-year olds) remains lacking.
objectiveTo assess the global burden of the disease associated with acne vulgaris for late adolescents (15-19-year olds) and provide an overview of the epidemiology, pathophysiology, and treatment options for acne in this population.
designDatabase summary study.
settingGlobal Burden of Disease Study 2010 database.
participantsGlobal Burden of Disease regions comprised countries with prevalence of acne vulgaris between the ages of 15 and 19 years. MAIN OUTCOMES AND MEASURES: Geographic region-level disability-adjusted life year rates (per 100,000 persons) associated with acne vulgaris in years 1990 through 2010. Median percentage change in disability-adjusted life year rates was estimated for each region across the specified study period. CONCLUSION AND RELEVANCE: Acne vulgaris-associated disease burden exhibits global distribution and has continued to grow in prevalence over time within this population. This continued growth suggests an unmet dermatologic need worldwide for this disorder and potential opportunities for improved access and delivery of dermatologic care. Our analysis of the literature reveals numerous opportunities for enhanced patient care. To that end, we highlight some of the effective and promising treatments currently available and address important factors, such as sex, nationality, genetics, pathophysiology, and diet, as they relate to acne vulgaris in late adolescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.