ArticlePhysica D. Nonlinear phenomena2016
Spatiotemporal dynamics of distributed synthetic genetic circuits.
Article in Physica D. Nonlinear phenomena, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Moran Model of Spatial Alignment in Microbial Colonies.Physica D. Nonlinear phenomena · 2019Article
- Bistability and oscillations in co-repressive synthetic microbial consortia.Quantitative biology (Beijing, China) · 2017Article
- Synthetic biology routes to bio-artificial intelligence.Essays in biochemistry · 2016Review
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Authors and funding
4 authors.
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Abstract
We propose and study models of two distributed synthetic gene circuits, toggle-switch and oscillator, each split between two cell strains and coupled via quorum-sensing signals. The distributed toggle switch relies on mutual repression of the two strains, and oscillator is comprised of two strains, one of which acts as an activator for another that in turn acts as a repressor. Distributed toggle switch can exhibit mobile fronts, switching the system from the weaker to the stronger spatially homogeneous state. The circuit can also act as a biosensor, with the switching front dynamics determined by the properties of an external signal. Distributed oscillator system displays another biosensor functionality: oscillations emerge once a small amount of one cell strain appears amid the other, present in abundance. Distribution of synthetic gene circuits among multiple strains allows one to reduce crosstalk among different parts of the overall system and also decrease the energetic burden of the synthetic circuit per cell, which may allow for enhanced functionality and viability of engineered cells.
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