ArticleIndian journal of dermatology
Cross-sectional Pilot Study of Antibiotic Resistance in Propionibacterium Acnes Strains in Indian Acne Patients Using 16S-RNA Polymerase Chain Reaction: A Comparison Among Treatment Modalities Including Antibiotics, Benzoyl Peroxide, and Isotretinoin.
Article in Indian journal of dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 48 citations in OpenAlex.
- Phage-Derived Endolysins TargetingAntibiotics (Basel, Switzerland) · 2026Review
- Emerging antimicrobial resistance amongJournal of family medicine and primary care · 2026Article
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- Unique genetic diversity of Propionibacterium acnes isolated from human facial skins in Thailand revealed by the multi-locus sequence typing scheme.BMC microbiology · 2025Article
- Gastrointestinal comorbidities in patients with acne vulgaris: A population-based retrospective study.JAAD international · 2025Article
- Antibiotics and Antimicrobial Resistance in Acne: Epidemiological Trends and Clinical Practice Considerations.The Yale journal of biology and medicine · 2022Review
- Nano-Therapeutics to Treat Acne Vulgaris.Indian journal of microbiology · 2022Review
- Activity of nadifloxacin and three other antimicrobial agents against Cutibacterium acnes isolated from patients with acne vulgaris.Journal of the European Academy of Dermatology and Venereology : JEADV · 2021Article
- Human Skin Microbiome: Impact of Intrinsic and Extrinsic Factors on Skin Microbiota.Microorganisms · 2021Review
- Oral Antibiotics for Acne.American journal of clinical dermatology · 2021Review
- Association of Antimicrobial Susceptibility and Treatment Outcome in Acne Vulgaris Patients: A Pilot Study.Journal of laboratory physicians · 2020Article
- Antibiotic Susceptibility of Cutibacterium acnes Strains Isolated from Israeli Acne Patients.Acta dermato-venereologica · 2020Article
- The Skin Microbiome: A New Actor in Inflammatory Acne.American journal of clinical dermatology · 2020Review
- Potential Role of the Microbiome in Acne: A Comprehensive Review.Journal of clinical medicine · 2019Review
- Acne, the Skin Microbiome, and Antibiotic Treatment.American journal of clinical dermatology · 2019Review
- Prospects of Phage Application in the Treatment of Acne Caused byFrontiers in microbiology · 2017Review
- New developments in acne treatment: role of combination adapalene-benzoylperoxide.Therapeutics and clinical risk management · 2016Review
- Methodology Series Module 3: Cross-sectional Studies.Indian journal of dermatologyArticle
- Correlation between Antimicrobial ResistantIndian journal of dermatologyArticle
- Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntibiotic resistance is a worldwide problem in acne patients due to regional prescription practices, patient compliance, and genomic variability in Propionibacterium acnes, though the effect of treatment on the resistance has not been comprehensively analyzed.
aimsOur primary objective was to assess the level of antibiotic resistance in the Indian patients and to assess whether there was a difference in the resistance across common treatment groups. SUBJECTS AND
methodsA cross-sectional, institutional based study was undertaken and three groups of patients were analyzed, treatment naïve, those on antibiotics and patients on benzoyl peroxide (BPO) and/isotretinoin. The follicular content was sampled and the culture was verified with 16S rRNA polymerase chain reaction, genomic sequencing, and pulsed-field gel electrophoresis. Minimum inhibitory concentration (MIC) assessment was done for erythromycin (ERY), azithromycin (AZI), clindamycin (CL), tetracycline (TET), doxycycline (DOX), minocycline (MINO), and levofloxacin (LEVO). The four groups of patients were compared for any difference in the resistant strains.
resultsOf the 52 P. acnes strains isolated (80 patients), high resistance was observed to AZI (100%), ERY (98%), CL (90.4%), DOX (44.2%), and TETs (30.8%). Low resistance was observed to MINO (1.9%) and LEVO (9.6%). Statistical difference was seen in the resistance between CL and TETs; DOX/LEVO and DOX/MINO (P < 0.001). High MIC90 (≥256 μg/ml) was seen with CL, macrolides, and TETs; moreover, low MIC90 was observed to DOX (16 μg/ml), MINO (8 μg/ml), and LEVO (4 μg/ml). Though the treatment group with isotretinoin/BPO had the least number of resistant strains there was no statistical difference in the antibiotic resistance among the various groups of patients.
conclusionsHigh resistance was seen among the P. acnes strains to macrolides-lincosamides (AZI and CL) while MINO and LEVO resistance was low.
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