ArticleEnvironmental health perspectives2016
An Informatics Approach to Evaluating Combined Chemical Exposures from Consumer Products: A Case Study of Asthma-Associated Chemicals and Potential Endocrine Disruptors.
Article in Environmental health perspectives, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Exposome influences: a multi-omics perspective on the combined toxic effects of pharmaceuticals and personal care products in Alzheimer's disease.Frontiers in toxicology · 2026Review
- Quantifying the Spatial and Temporal Distributions of Volatile Chemical Products (VCPs) in the Greater Houston Area.Environmental science & technology · 2025Article
- Article
- Relationship between the use of hair products and urine benzophenone-3: the Korean National Environmental Health Survey (KoNEHS) cycle 4.Annals of occupational and environmental medicine · 2024Article
- Identifying Toxic Consumer Products: A Novel Data Set Reveals Air Emissions of Potent Carcinogens, Reproductive Toxicants, and Developmental Toxicants.Environmental science & technology · 2023Article
- Data Mining Approaches for Assessing Chemical Coexposures Using Consumer Product Purchase Data.Risk analysis : an official publication of the Society for Risk Analysis · 2021Article
- The Unified Medical Language System at 30 Years and How It Is Used and Published: Systematic Review and Content Analysis.JMIR medical informatics · 2021Review
- Mining of Consumer Product Ingredient and Purchasing Data to Identify Potential Chemical Coexposures.Environmental health perspectives · 2021Article
- Article
- Criteria pollutant impacts of volatile chemical products informed by near-field modeling.Nature sustainability · 2020Article
- Generating the Blood Exposome Database Using a Comprehensive Text Mining and Database Fusion Approach.Environmental health perspectives · 2019Article
- Exposure to bisphenol A: current levels from food intake are toxic to human cells.Molecular biology reports · 2019Article
- Consumer product chemical weight fractions from ingredient lists.Journal of exposure science & environmental epidemiology · 2018Article
- The role of pollutants in type 2 diabetes mellitus (T2DM) and their prospective impact on phytomedicinal treatment strategies.Environmental monitoring and assessment · 2018Article
- High-Throughput Analysis of Ovarian Cycle Disruption by Mixtures of Aromatase Inhibitors.Environmental health perspectives · 2017Article
- Emerging exposures of developmental toxicants.Current opinion in pediatrics · 2017Review
- An Informatics Approach to Reading the Label: Identifying Common Chemical Mixtures in Personal Care Products.Environmental health perspectives · 2016Article
- Characterization and prediction of chemical functions and weight fractions in consumer products.Toxicology reports · 2016Article
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSimultaneous or sequential exposure to multiple environmental stressors can affect chemical toxicity. Cumulative risk assessments consider multiple stressors but it is impractical to test every chemical combination to which people are exposed. New methods are needed to prioritize chemical combinations based on their prevalence and possible health impacts.
objectivesWe introduce an informatics approach that uses publicly available data to identify chemicals that co-occur in consumer products, which account for a significant proportion of overall chemical load.
methodsFifty-five asthma-associated and endocrine disrupting chemicals (target chemicals) were selected. A database of 38,975 distinct consumer products and 32,231 distinct ingredient names was created from online sources, and PubChem and the Unified Medical Language System were used to resolve synonymous ingredient names. Synonymous ingredient names are different names for the same chemical (e.g., vitamin E and tocopherol).
resultsNearly one-third of the products (11,688 products, 30%) contained ≥ 1 target chemical and 5,229 products (13%) contained > 1. Of the 55 target chemicals, 31 (56%) appear in ≥ 1 product and 19 (35%) appear under more than one name. The most frequent three-way chemical combination (2-phenoxyethanol, methyl paraben, and ethyl paraben) appears in 1,059 products. Further work is needed to assess combined chemical exposures related to the use of multiple products.
conclusionsThe informatics approach increased the number of products considered in a traditional analysis by two orders of magnitude, but missing/incomplete product labels can limit the effectiveness of this approach. Such an approach must resolve synonymy to ensure that chemicals of interest are not missed. Commonly occurring chemical combinations can be used to prioritize cumulative toxicology risk assessments. CITATION: Gabb HA, Blake C. 2016. An informatics approach to evaluating combined chemical exposures from consumer products: a case study of asthma-associated chemicals and potential endocrine disruptors. Environ Health Perspect 124:1155-1165; http://dx.doi.org/10.1289/ehp.1510529.
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