ArticleEnvironmental health perspectives2016
Relation between in Utero Arsenic Exposure and Birth Outcomes in a Cohort of Mothers and Their Newborns from New Hampshire.
Article in Environmental health perspectives, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 3 of them syntheses that pooled it.
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Who cites it
83 citing papers in PubMed, 3 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health.Communications biology · 2022Pooled it
- Provision of folic acid for reducing arsenic toxicity in arsenic-exposed children and adults.The Cochrane database of systematic reviews · 2021Pooled it
- Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth.Nature communications · 2021Pooled it
- Arsenic Exposure During Pregnancy: Impacts to Maternal and Offspring Cardiovascular Health.Medical research archives · 2026Article
- Time-Varying Exposure to Element Mixtures and Children's Cognition at 5 Years of Age: Findings from the New Hampshire Birth Cohort Study.Environmental health perspectives · 2026Article
- Adherence to the EAT-Lancet Planetary Health Diet during pregnancy and associations with preterm birth and infant size: a prospective analysis from the New Hampshire Birth Cohort.The American journal of clinical nutrition · 2026Article
- 2020-2025 Dietary Guidelines for Americans in Pregnancy: Adherence Shortfalls and Associations with Gestational Weight Gain.The Journal of nutrition · 2026Article
- Public Water Arsenic and Birth Outcomes in the Environmental Influences on Child Health Outcomes Cohort.JAMA network open · 2025Observational
- Prenatal per- and polyfluoroalkyl substances and blood pressure trajectories in the New Hampshire Birth Cohort Study.International journal of hygiene and environmental health · 2025Article
- Review
- Using a neural network to derive early childhood neurodevelopmental profiles in the New Hampshire Birth Cohort Study.BMJ public health · 2025Article
- Cancer incidence associations with drinking water arsenic levels and disinfection methods in Maine, USA.Journal of water and health · 2024Article
- Fish intake and mercury exposure in young children.Environmental research · 2024Article
- Association between gestational arsenic exposure and infant physical development: a prospective cohort study.BMC public health · 2024Article
- Single-cell RNA sequencing reveals placental response under environmental stress.Nature communications · 2024Article
- Association of diet with per- and polyfluoroalkyl substances in plasma and human milk in the New Hampshire Birth Cohort Study.The Science of the total environment · 2024Article
- Plasma per- and polyfluoroalkyl substance mixtures during pregnancy and duration of breastfeeding in the New Hampshire birth cohort study.International journal of hygiene and environmental health · 2024Article
- Measuring Greenspace in Rural Areas for Studies of Birth Outcomes: A Comparison of Street View Data and Satellite Data.GeoHealth · 2024Article
- Association between Mediterranean diet and metal mixtures concentrations in pregnant people from the New Hampshire Birth Cohort Study.The Science of the total environment · 2024Article
- Associations of Perinatal Metal and Metalloid Exposures with Early Child Behavioral Development Over Time in the New Hampshire Birth Cohort Study.Exposure and health · 2024Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundStudies suggest that arsenic exposure influences birth outcomes; however, findings are mixed.
objectiveWe assessed in utero arsenic exposure in relation to birth outcomes and whether maternal prepregnancy weight and infant sex modified the associations.
methodsAmong 706 mother-infant pairs exposed to low levels of arsenic through drinking water and diet, we assessed in utero arsenic exposure using maternal second-trimester urinary arsenic, maternal prepregnancy weight through self-report, and birth outcomes from medical records.
resultsMedian (interquartile range) of total urinary arsenic [tAs; inorganic arsenic (iAs) + monomethylarsonic acid (MMA) + dimethylarsinic acid (DMA)] was 3.4 μg/L (1.7-6.0). In adjusted linear models, each doubling of tAs was associated with a 0.10-cm decrease (95% CI: -0.19, -0.01) in head circumference. Results were similar for MMA and DMA. Ln(tAs) and ln(DMA) were positively associated with birth length in infant males only; among males, each doubling of tAs was associated with a 0.28-cm increase (95% CI: 0.09, 0.46) in birth length (pinteraction = 0.04). Results were similar for DMA. Additionally, arsenic exposure was inversely related to ponderal index, and associations differed by maternal weight. Each ln(tAs) doubling of tAs was associated with a 0.55-kg/m3 lower (95% CI: -0.82, -0.28, p < 0.001) ponderal index for infants of overweight/obese, but not normal-weight, mothers (pinteraction < 0.01). Finally, there was a significant interaction between maternal weight status, infant sex, and arsenic exposure on birth weight (pinteraction = 0.03). In girls born of overweight/obese mothers, each doubling of tAs was associated with a 62.9-g decrease (95% CI: -111.6, -14.2) in birth weight, though the association was null in the other strata.
conclusionsLow-level arsenic exposure may affect fetal growth, and the associations may be modified by maternal weight status and infant sex. CITATION: Gilbert-Diamond D, Emond JA, Baker ER, Korrick SA, Karagas MR. 2016. Relation between in utero arsenic exposure and birth outcomes in a cohort of mothers and their newborns from New Hampshire. Environ Health Perspect 124:1299-1307; http://dx.doi.org/10.1289/ehp.1510065.
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