ArticlePloS one2016
Population Structure and Antimicrobial Resistance Profiles of Streptococcus suis Serotype 2 Sequence Type 25 Strains.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 67 citations in OpenAlex.
- Meningitis in a French pig farmer caused by a serotype 2ASM case reports · 2026Article
- Molecular epidemiology and antimicrobial resistance of humanFrontiers in public health · 2026Article
- Developing genome typing strategies for the emerging zoonotic pathogenJournal of clinical microbiology · 2025Article
- Genomic and Antimicrobial Resistance Analysis of an ST25Pathogens (Basel, Switzerland) · 2025Article
- The genotypic characterization ofFrontiers in microbiology · 2025Article
- Article
- Molecular characterization of Streptococcus suis isolates recovered from diseased pigs in Europe.Veterinary research · 2024Article
- Analysis of fine-scale phylogeny of Burkholderia pseudomallei in relation to regional geography and drug susceptibility in Thailand.Scientific reports · 2024Article
- Identification and genomic analyses of aHeliyon · 2024Article
- Genomic epidemiology inHeliyon · 2024Review
- Epidemiology and genetic diversity of Streptococcus suis in smallhold swine farms in the Philippines.Scientific reports · 2023Article
- Evaluating the Antibacterial and Antivirulence Activities of Floxuridine againstInternational journal of molecular sciences · 2023Article
- Article
- Population structure and genetic diversity ofFrontiers in microbiology · 2023Article
- How Streptococcus suis escapes antibiotic treatments.Veterinary research · 2022Review
- Genetic diversity and variation in antimicrobial-resistance determinants of non-serotype 2Microbial genomics · 2022Article
- Characterization of integrative and conjugative elements carrying antibiotic resistance genes ofFrontiers in microbiology · 2022Article
- Article
- Genomic and pathogenic investigations ofEmerging microbes & infections · 2021Article
- Anatomical Site, Typing, Virulence Gene Profiling, Antimicrobial Susceptibility and Resistance Genes ofAntibiotics (Basel, Switzerland) · 2021Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Strains of serotype 2 Streptococcus suis are responsible for swine and human infections. Different serotype 2 genetic backgrounds have been defined using multilocus sequence typing (MLST). However, little is known about the genetic diversity within each MLST sequence type (ST). Here, we used whole-genome sequencing to test the hypothesis that S. suis serotype 2 strains of the ST25 lineage are genetically heterogeneous. We evaluated 51 serotype 2 ST25 S. suis strains isolated from diseased pigs and humans in Canada, the United States of America, and Thailand. Whole-genome sequencing revealed numerous large-scale rearrangements in the ST25 genome, compared to the genomes of ST1 and ST28 S. suis strains, which result, among other changes, in disruption of a pilus island locus. We report that recombination and lateral gene transfer contribute to ST25 genetic diversity. Phylogenetic analysis identified two main and distinct Thai and North American clades grouping most strains investigated. These clades also possessed distinct patterns of antimicrobial resistance genes, which correlated with acquisition of different integrative and conjugative elements (ICEs). Some of these ICEs were found to be integrated at a recombination hot spot, previously identified as the site of integration of the 89K pathogenicity island in serotype 2 ST7 S. suis strains. Our results highlight the limitations of MLST for phylogenetic analysis of S. suis, and the importance of lateral gene transfer and recombination as drivers of diversity in this swine pathogen and zoonotic agent.
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