ArticleBiological psychiatry2016
Callosal Abnormalities Across the Psychosis Dimension: Bipolar Schizophrenia Network on Intermediate Phenotypes.
Article in Biological psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 40 citations in OpenAlex.
- Evaluation of Morphometric Findings of Corpus Callosum in Schizophrenia Patients with Magnetic Resonance Imaging and Comparison with Healthy Individuals.Journal of clinical medicine · 2025Article
- The modular mind and psychiatry: toward clinical integration with a focus on self-disorders.Frontiers in psychology · 2025Article
- Psychosis superspectrum II: neurobiology, treatment, and implications.Molecular psychiatry · 2024Review
- Distributed genetic effects of the corpus callosum subregions suggest links to neuropsychiatric disorders and related traits.Acta neuropsychiatrica · 2023Article
- A morphological study of the shape of the corpus callosum in normal, schizophrenic and bipolar patients.Journal of anatomy · 2023Article
- Article
- Scaling Principles of White Matter Connectivity in the Human and Nonhuman Primate Brain.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Mapping the expression of an ANK3 isoform associated with bipolar disorder in the human brain.Translational psychiatry · 2022Article
- SARS-CoV-2-associated first episode of acute mania with psychotic features.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2021Article
- Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): I. Psychosis superspectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2020Article
- Altered frontal white matter asymmetry and its implications for cognition in schizophrenia: A tractography study.NeuroImage. Clinical · 2019Article
- Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder.Translational psychiatry · 2018Article
- Discovery biology of neuropsychiatric syndromes (DBNS): a center for integrating clinical medicine and basic science.BMC psychiatry · 2018Article
- Connectivity-enhanced diffusion analysis reveals white matter density disruptions in first episode and chronic schizophrenia.NeuroImage. Clinical · 2018Article
- MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume.International journal of clinical and health psychology : IJCHPArticle
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9 authors at 5 institutions in 2 countries.
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Abstract
backgroundThe corpus callosum has been implicated in the pathogenesis of schizophrenia and bipolar disorder. However, it is unclear whether corpus callosum alterations are related to the underlying familial diathesis for psychotic disorders. We examined the corpus callosum and its subregion volumes and their relationship to cognition, psychotic symptoms, and age in probands with schizophrenia (SZ), psychotic bipolar disorder (PBD), and schizoaffective disorder; their first-degree relatives; and healthy control subjects.
methodsWe present findings from morphometric and neurocognitive analyses of 1381 subjects (SZ probands, n = 224; PBD probands, n = 190; schizoaffective disorder probands, n = 142; unaffected relatives, n = 483 [SZ relatives, n = 195; PBD relatives, n = 175; schizoaffective disorder relatives, n = 113]; control subjects, n = 342). Magnetization prepared rapid acquisition gradient-echo T1 scans across five sites were obtained using 3-tesla magnets. Image processing was done using FreeSurfer Version 5.1. Neurocognitive function was measured using the Brief Assessment of Cognition in Schizophrenia scale.
resultsAnterior and posterior splenial volumes were significantly reduced across the groups. The SZ and PBD probands showed robust and significant reductions, whereas relatives showed significant reductions of intermediate severity. The splenial volumes were positively but differentially correlated with aspects of cognition in the probands and their relatives. Proband groups showed a significant age-related decrease in the volume of the anterior splenium compared with control subjects. Among the psychosis groups, the anterior splenium in probands with PBD showed a stronger correlation with psychotic symptoms, as shown by the Positive and Negative Syndrome Scale. All five subregions showed significantly high familiality.
conclusionsThe splenial volumes were significantly reduced across the psychosis dimension. However, this volume reduction impacts cognition and clinical manifestation of the illnesses differentially.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.