Evidence map›Paper›PMID 26954541›Full record

ArticleDevelopmental cell2016

Chromatin Condensation and Enucleation in Red Blood Cells: An Open Question.

Margaret H Baron, Jeffrey Barminko

Abstract readComment
PubMed Publisher
In one paragraph

Article in Developmental cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Margaret H BaronDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: margaret.baron@mssm.edu.
Jeffrey BarminkoDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Funding

Induction and Specification of Hematopoietic MesodermR01HL062248 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI BARON, MARGARET H · 2000 to 2016
$5.5M
Regulation of Erythropoiesis by the VDR Nuclear Receptor Transcription FactorR01DK102945 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BARON, MARGARET H · 2015 to 2022
$4.0M
Research Training Program in Molecular and Cellular HematologyT32HL094283 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BARON, MARGARET H · 2009 to 2013
$908k
NHLBI NIH HHS R01 HL062248NHLBI NIH HHS T32 HL094283NIDDK NIH HHS R01 DK102945
6 · The paper itself

Abstract

Differentiating erythroid cells undergo dramatic changes in morphology, with reduction in cell size, chromatin and nuclear condensation, and enucleation. In this issue of Developmental Cell, Zhao et al. (2016) show that these events are associated with the formation of transient, recurring nuclear openings and selective histone release mediated by caspase-3.

Indexed as

AnimalsApoptosisCaspase 3Cell NucleusErythroblastsErythropoiesisCaspase 3

Identifiers

PMID26954541

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.