Evidence map›Paper›PMID 26954333›Full record

ReviewNature reviews. Urology2016

Enhancing active surveillance of prostate cancer: the potential of exercise medicine.

Daniel A Galvão, Dennis R Taaffe, Nigel Spry, Robert A Gardiner, Renea Taylor, Gail P Risbridger, Mark Frydenberg, Michelle Hill, Suzanne K Chambers, Phillip Stricker and 4 more

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Daniel A GalvãoExercise Medicine Research Institute, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia 6027, Australia.
Dennis R TaaffeExercise Medicine Research Institute, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia 6027, Australia.
Nigel SpryExercise Medicine Research Institute, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia 6027, Australia.
Robert A GardinerExercise Medicine Research Institute, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia 6027, Australia.
Renea TaylorCancer Program, Monash Biomedicine Discovery Institute and Department of Physiology, Monash University, Melbourne, Victoria 3800, Australia.
Gail P RisbridgerCancer Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria 3800, Australia.
Mark FrydenbergDepartment of Surgery, Monash University, Melbourne, Victoria 3800, Australia.
Michelle HillThe University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Queensland 4072, Australia.
Suzanne K ChambersExercise Medicine Research Institute, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia 6027, Australia.
Phillip StrickerSuite 1001, St Vincent's Prostate Cancer Centre, 438 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia.
Tom ShannonSuite 32, Hollywood Specialist Centre, 95 Monash Avenue, Nedlands Western Australia 6009, Australia.
Dickon HayneDepartment of Surgery, University of Western Australia (M704), 35 Stirling Highway, Crawley, Western Australia 6009, Australia.
Eva ZopfExercise Medicine Research Institute, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia 6027, Australia.
Robert U NewtonExercise Medicine Research Institute, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia 6027, Australia.
Edith Cowan University · AUMonash University · AUGerman Sport University Cologne · DEHollywood Orthopaedic Group · AUProstate Cancer Foundation of Australia · AUUniversity of Queensland · AUUniversity of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Active surveillance (AS) is a strategy for the management of patients with low-risk, localized prostate cancer, in which men undergo regular monitoring of serum PSA levels and tumour characteristics, using multiparametric MRI and repeat biopsy sampling, to identify signs of disease progression. This strategy reduces overtreatment of clinically insignificant disease while also preserving opportunities for curative therapy in patients whose disease progresses. Preliminary studies of lifestyle interventions involving basic exercise advice have indicated that exercise reduces the numbers of patients undergoing active treatment, as well as modulating the biological processes involved in tumour progression. Therefore, preliminary evidence suggests that lifestyle and/or exercise interventions might have therapeutic potential in this growing population of men with prostate cancer. However, several important issues remain unclear: the exact value of different types of lifestyle and exercise medicine interventions during AS; the biological mechanisms of exercise in delaying disease progression; and the influence of the anxieties and distress created by having a diagnosis of cancer without then receiving active treatment. Future studies are required to confirm and expand these findings and determine the relative contributions of each lifestyle component to specific end points and patient outcomes during AS.

Indexed as

Clinical Trials as TopicExercise TherapyHumansMaleNeoplasm GradingProstate-Specific AntigenProstatic NeoplasmsWatchful WaitingProstate-Specific Antigen

Identifiers

PMID26954333
OpenAlexW2294315477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.