ArticleJournal of the American Chemical Society2016
Total Synthesis of (-)-Mandelalide A Exploiting Anion Relay Chemistry (ARC): Identification of a Type II ARC/CuCN Cross-Coupling Protocol.
Article in Journal of the American Chemical Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Inter-and Intramolecular (4+3) Cycloadditions With Epoxy Allylsilanes as Dienophiles.Chemistry, an Asian journal · 2026Article
- Site-directed late-stage diversification of macrocyclic nannocystins facilitating anticancer SAR and mode of action studies.RSC medicinal chemistry · 2023Article
- Article
- The Tetrahydrofuran Motif in Polyketide Marine Drugs.Marine drugs · 2022Review
- Evolution of Anion Relay Chemistry: Construction of Architecturally Complex Natural Products.Accounts of chemical research · 2020Review
- Merging Asymmetric [1,2]-Additions of Lithium Acetylides to Carbonyls with Type II Anion Relay Chemistry.Organic letters · 2019Article
- Generation of Dithianyl and Dioxolanyl Radicals Using Photoredox Catalysis: Application in the Total Synthesis of the Danshenspiroketallactones via Radical Relay Chemistry.Organic letters · 2019Article
- Bran-New Four-Molecule and Five-Molecule Cascade Reactions for One-Pot Synthesis of Pyrano[3,2-ACS omega · 2018Article
- Total Synthesis of the Marine Phosphomacrolide, (-)-Enigmazole A, Exploiting Multicomponent Type I Anion Relay Chemistry (ARC) in Conjunction with a Late-Stage Petasis-Ferrier Union/Rearrangement.The Journal of organic chemistry · 2018Article
- Synthetic Access to the Mandelalide Family of Macrolides: Development of an Anion Relay Chemistry Strategy.The Journal of organic chemistry · 2018Article
- Pot-Economy Autooxidative Condensation of 2-Aryl-2-lithio-1,3-dithianes.The Journal of organic chemistry · 2018Article
- α-Silyl Amides: Effective Bifunctional Lynchpins for Type I Anion Relay Chemistry.Organic letters · 2017Article
- Anion Relay Chemistry: Development of an Effective Diastereoselective [3+2] Annulation Tactic Exploiting an Aldol/Brook Rearrangement/Cyclization Cascade.Angewandte Chemie (International ed. in English) · 2017Article
- Design, Synthesis, and Application of Polymer-Supported Silicon-Transfer Agents for Cross-Coupling Reactions with Organolithium Reagents.The Journal of organic chemistry · 2017Article
- New Mandelalides Expand a Macrolide Series of Mitochondrial Inhibitors.Journal of medicinal chemistry · 2017Article
- Type II Anion Relay Chemistry: Conformational Constraints To Achieve Effective [1,5]-Vinyl Brook Rearrangements.Journal of the American Chemical Society · 2017Article
- A modified protocol for the detection of three different mRNAs with a new-generation in situ hybridization chain reaction on frozen sections.Journal of molecular histology · 2016Article
- Enantioselective Alcohol C-H Functionalization for Polyketide Construction: Unlocking Redox-Economy and Site-Selectivity for Ideal Chemical Synthesis.Journal of the American Chemical Society · 2016Article
- Article
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Authors and funding
4 authors.
Funding
Abstract
Anion relay chemistry (ARC), an effective, multicomponent union tactic, was successfully employed for the total synthesis of the highly cytotoxic marine macrolide (-)-mandelalide A (1). The northern hemisphere was constructed via a new type II ARC/CuCN cross-coupling tactic, while the southern hemisphere was secured via a highly efficient four-component type I ARC union. Importantly, the synthesis of 1 showcases ARC as a rapid, scalable coupling strategy for the union of simple readily available building blocks to access diverse complex molecular fragments with excellent stereochemical control.
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