ArticlePloS one2016
The HEX 110 Hexamerin Is a Cytoplasmic and Nucleolar Protein in the Ovaries of Apis mellifera.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Transcriptomic analyses of labial glands and gut tissue from two wax moths, Achroia grisella and Galleria mellonella.G3 (Bethesda, Md.) · 2026Article
- Conserved but mechanistically diverse piRNA defence against endogenous retroviruses in insects.EMBO reports · 2026Article
- Improved reference quality genome sequence of the plastic-degrading greater wax moth, Galleria mellonella.G3 (Bethesda, Md.) · 2024Article
- The Honey Bee Colony's Criterion for Candidate Selection: "Ongoing" or "One-Shot"?Animals : an open access journal from MDPI · 2024Article
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- Gut microbiota-driven regulation of queen bee ovarian metabolism.Microbiology spectrum · 2023Article
- Improving the Brightness of Pyronin Fluorophore Systems through Quantum-Mechanical Predictions.The journal of physical chemistry letters · 2022Article
- Roles of Insect Oenocytes in Physiology and Their Relevance to Human Metabolic Diseases.Frontiers in insect science · 2022Review
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- Characterization and Developmental Expression Patterns of Four Hexamerin Genes in the Bumble Bee, Bombus terrestris (Hymenoptera: Apidae).Journal of insect science (Online) · 2021Article
- What fuels the fly: Energy metabolism inScience advances · 2021Review
- Developmental expression and evolution of hexamerin and haemocyanin from Folsomia candida (Collembola).Insect molecular biology · 2019Article
- In-depth Proteome of the Hypopharyngeal Glands of Honeybee Workers Reveals Highly Activated Protein and Energy Metabolism in Priming the Secretion of Royal Jelly.Molecular & cellular proteomics : MCP · 2019Article
- Article
- Brain gene expression analyses in virgin and mated queens of fire ants reveal mating-independent and socially regulated changes.Ecology and evolution · 2018Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hexamerins are insect storage proteins abundantly secreted by the larval fat body into the haemolymph. The canonical role of hexamerins consists of serving as an amino acid reserve for development toward the adult stage. However, in Apis mellifera, immunofluorescence assays coupled to confocal laser-scanning microscopy, and high-throughput sequencing, have recently shown the presence of hexamerins in other organs than the fat body. These findings have led us to study these proteins with the expectation of uncovering additional functions in insect development. We show here that a honeybee hexamerin, HEX 110, localizes in the cytoplasm and nucleus of ovarian cells. In the nucleus of somatic and germline cells, HEX 110 colocalized with a nucleolar protein, fibrillarin, suggesting a structural or even regulatory function in the nucleolus. RNase A provoked the loss of HEX 110 signals in the ovarioles, indicating that the subcellular localization depends on RNA. This was reinforced by incubating ovaries with pyronin Y, a RNA-specific dye. Together, the colocalization with fibrillarin and pyronin Y, and the sensitivity to RNase, highlight unprecedented roles for HEX110 in the nucleolus, the nuclear structure harbouring the gene cluster involved in ribosomal RNA production. However, the similar patterns of HEX 110 foci distribution in the active and inactive ovaries of queens and workers preclude its association with the functional status of these organs.
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