ReviewCurrent opinion in neurology2016
Interictal high-frequency oscillations in focal human epilepsy.
Review in Current opinion in neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 63 citations in OpenAlex.
- Review
- Non-invasive neuromodulation for drug-resistant epilepsy: a contemporary structured review of mechanisms, clinical evidence and future directions.Frontiers in neurology · 2026Review
- Very High-Frequency Oscillations in Mesial Temporal Lobe Epilepsy: Identifying the Epileptogenic Zone.Annals of clinical and translational neurology · 2025Article
- Predicting seizure onset zones from interictal intracranial EEG using functional connectivity and machine learning.Scientific reports · 2025Article
- Using high-frequency oscillations from brief intraoperative neural recordings to predict the seizure onset zone.Communications medicine · 2024Article
- The interictal suppression hypothesis is the dominant differentiator of seizure onset zones in focal epilepsy.Brain : a journal of neurology · 2024Article
- Cell-type specific and multiscale dynamics of human focal seizures in limbic structures.Brain : a journal of neurology · 2023Article
- The role of superficial and deep layers in the generation of high frequency oscillations and interictal epileptiform discharges in the human cortex.Scientific reports · 2023Article
- Phase-Amplitude Coupling Localizes Pathologic Brain with Aid of Behavioral Staging in Sleep.Life (Basel, Switzerland) · 2023Article
- Protocol for multicentre comparison of interictal high-frequency oscillations as a predictor of seizure freedom.Brain communications · 2022Article
- Blinded study: prospectively defined high-frequency oscillations predict seizure outcome in individual patients.Brain communications · 2021Article
- Periodic discharges with high frequency oscillations recorded from a cerebellar gangliocytoma in an epileptic infant.Surgical neurology international · 2021Article
- High frequency oscillations in epileptic and non-epileptic human hippocampus during a cognitive task.Scientific reports · 2020Observational
- Multicenter intracranial EEG dataset for classification of graphoelements and artifactual signals.Scientific data · 2020Article
- Unsupervised machine-learning classification of electrophysiologically active electrodes during human cognitive task performance.Scientific reports · 2019Article
- Multi-feature localization of epileptic foci from interictal, intracranial EEG.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2019Article
- A Magnetoencephalography Study of Pediatric Interictal Neuromagnetic Activity Changes and Brain Network Alterations Caused by Epilepsy in the High Frequency (80-1000 Hz).IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2019Article
- Automated Detection of High-Frequency Oscillations in Epilepsy Based on a Convolutional Neural Network.Frontiers in computational neuroscience · 2019Article
- A Stacked Sparse Autoencoder-Based Detector for Automatic Identification of Neuromagnetic High Frequency Oscillations in Epilepsy.IEEE transactions on medical imaging · 2018Article
- Physiological and pathological high frequency oscillations in focal epilepsy.Annals of clinical and translational neurology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
purpose of reviewLocalization of focal epileptic brain is critical for successful epilepsy surgery and focal brain stimulation. Despite significant progress, roughly half of all patients undergoing focal surgical resection, and most patients receiving focal electrical stimulation, are not seizure free. There is intense interest in high-frequency oscillations (HFOs) recorded with intracranial electroencephalography as potential biomarkers to improve epileptogenic brain localization, resective surgery, and focal electrical stimulation. The present review examines the evidence that HFOs are clinically useful biomarkers. RECENT
findingsPerforming the PubMed search 'High-Frequency Oscillations and Epilepsy' for 2013-2015 identifies 308 articles exploring HFO characteristics, physiological significance, and potential clinical applications. SUMMARY: There is strong evidence that HFOs are spatially associated with epileptic brain. There remain, however, significant challenges for clinical translation of HFOs as epileptogenic brain biomarkers: Differentiating true HFO from the high-frequency power changes associated with increased neuronal firing and bandpass filtering sharp transients. Distinguishing pathological HFO from normal physiological HFO. Classifying tissue under individual electrodes as normal or pathological. Sharing data and algorithms so research results can be reproduced across laboratories. Multicenter prospective trials to provide definitive evidence of clinical utility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.