ReviewCurrent opinion in neurology2016
A developmental neuroscience approach to the search for biomarkers in autism spectrum disorder.
Review in Current opinion in neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Cannabidiol blood metabolite levels after cannabidiol treatment are associated with broadband EEG changes and improvements in visuomotor and non-verbal cognitive abilities in boys with autism requiring higher levels of support.Translational psychiatry · 2026Trial
- Cannabidiol blood metabolite levels after cannabidiol treatment are associated with broadband EEG changes and improvements in visuomotor and non-verbal cognitive abilities in boys with autism requiring higher levels of support.medRxiv : the preprint server for health sciences · 2025Article
- Should We Continue to Tell Autistic People that Their Brains are Different?Psychological reports · 2025Review
- Neurobiological basis of autism spectrum disorder: mini review.Frontiers in psychology · 2025Review
- Feasibility of a 2-minute eye-tracking protocol to support the early identification of autism.Scientific reports · 2024Article
- Eye Gaze in Autism Spectrum Disorder: A Review of Neural Evidence for the Eye Avoidance Hypothesis.Journal of autism and developmental disorders · 2023Review
- The Autism Biomarkers Consortium for Clinical Trials: Initial Evaluation of a Battery of Candidate EEG Biomarkers.The American journal of psychiatry · 2023Article
- Annual Research Review: Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND)-a systems neuroscience approach to common developmental disorders.Journal of child psychology and psychiatry, and allied disciplines · 2021Review
- The future of General Movement Assessment: The role of computer vision and machine learning - A scoping review.Research in developmental disabilities · 2021Article
- Use of longitudinal EEG measures in estimating language development in infants with and without familial risk for autism spectrum disorder.Neurobiology of language (Cambridge, Mass.) · 2020Article
- Neonatal EEG linked to individual differences in socioemotional outcomes and autism risk in toddlers.Developmental psychobiology · 2019Article
- Longitudinal EEG power in the first postnatal year differentiates autism outcomes.Nature communications · 2019Article
- Observational
- Investigating Potential Biomarkers in Autism Spectrum Disorder.Frontiers in integrative neuroscience · 2019Article
- Self-Regulation of the Fusiform Face Area in Autism Spectrum: A Feasibility Study With Real-Time fMRI Neurofeedback.Frontiers in human neuroscience · 2019Article
- Diagnostic accuracy of the ADOS and ADOS-2 in clinical practice.European child & adolescent psychiatry · 2018Article
- Biomarkers in Autism Spectrum Disorder: Challenges, Advances, and the Need for Biomarkers of Relevance to Public Health.Focus (American Psychiatric Publishing) · 2018Review
- An agenda for 21st century neurodevelopmental medicine: lessons from autism.Revista de neurologia · 2018Article
- Visual search performance in infants associates with later ASD diagnosis.Developmental cognitive neuroscience · 2018Article
- Differences in Cortical Structure and Functional MRI Connectivity in High Functioning Autism.Frontiers in neurology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewThe delineation of biomarkers in autism spectrum disorder (ASD) offers a promising approach to inform precision-medicine-based approaches to ASD diagnosis and treatment and to move toward a mechanistic description of the disorder. However, biomarkers with sufficient sensitivity or specificity for clinical application in ASD are yet to be realized. Here, we review recent evidence for early, low-level alterations in brain and behavior development that may offer promising avenues for biomarker development in ASD. RECENT
findingsAccumulating evidence suggests that signs associated with ASD may unfold in a manner that maps onto the hierarchical organization of brain development. Genetic and neuroimaging evidence points towards perturbations in brain development early in life, and emerging evidence indicates that sensorimotor development may be among the earliest emerging signs associated with ASD, preceding social and cognitive impairment. SUMMARY: The search for biomarkers of risk, prediction and stratification in ASD may be advanced through a developmental neuroscience approach that looks outside of the core signs of ASD and considers the bottom-up nature of brain development alongside the dynamic nature of development over time. We provide examples of assays that could be incorporated in studies to target low-level circuits.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.