ArticlePloS one2016
Excessive Pro-Inflammatory Serum Cytokine Concentrations in Virulent Canine Babesiosis.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Sepsis in Dogs and Cats-Consensus Definition and Clinical Criteria.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Pooled it
- Liver histopathology in dogs with naturally acquiredFrontiers in veterinary science · 2026Article
- Thromboinflammation in dogs with virulent babesiosis.Frontiers in veterinary science · 2026Article
- Metabolomics Insights into Salivary Profile in Dogs withBiomolecules · 2025Article
- Successful Transmammary Treatment ofPathogens (Basel, Switzerland) · 2024Article
- The Diverse Pathogenicity of VariousPathogens (Basel, Switzerland) · 2023Review
- Serum proteome profiling of naturally acquired Babesia rossi infection in dogs.Scientific reports · 2023Article
- Pathogenesis of Anemia in Canine Babesiosis: Possible Contribution of Pro-Inflammatory Cytokines and Chemokines-A Review.Pathogens (Basel, Switzerland) · 2023Review
- The dataset for the inflammatory response during experimental infection and treatment of dogs withData in brief · 2022Article
- Serial analysis of blood biomarker concentrations in dogs with pneumonia, septic peritonitis, and pyometra.Journal of veterinary internal medicine · 2022Article
- Erythrocyte sedimentation rate, C-reactive protein, and interleukin-6 as inflammatory biomarkers in dogs naturally infected withVeterinary world · 2021Article
- Disorders in Blood Circulation As a Probable Cause of Death in Dogs Infected withJournal of veterinary research · 2021Article
- Combined Untargeted and Targeted Metabolomics Approaches Reveal Urinary Changes of Amino Acids and Energy Metabolism in Canine Babesiosis With Different Levels of Kidney Function.Frontiers in microbiology · 2021Article
- Evaluation of inflammatory biomarkers in goats naturally infected with Babesia ovis.Parasitology research · 2020Article
- Neutrophil Myeloperoxidase Index in Dogs With Babesiosis Caused byFrontiers in veterinary science · 2020Article
- Babesia divergens glycosylphosphatidylinositols modulate blood coagulation and induce Th2-biased cytokine profiles in antigen presenting cells.Biochimie · 2019Article
- Hyponatraemia and Syndrome of Inappropriate Antidiuretic Hormone Secretion in Non-azotaemic Dogs with Babesiosis Associated with Decreased Arterial Blood Pressure.Journal of veterinary research · 2019Article
- The haematological, proinflammatory cytokines and IgG changes during an ovine experimental theileriosis.The Onderstepoort journal of veterinary research · 2019Article
- Biomarker Guided Diagnosis of Septic Peritonitis in Dogs.Frontiers in veterinary science · 2019Article
- Prevalence of canine Babesia and Ehrlichia co-infection and the predictive value of haematology.The Onderstepoort journal of veterinary research · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Babesia rossi infection causes a severe inflammatory response in the dog, which is the result of the balance between pro- and anti-inflammatory cytokine secretion. The aim of this study was to determine whether changes in cytokine concentrations were present in dogs with babesiosis and whether it was associated with disease outcome. Ninety-seven dogs naturally infected with B. rossi were studied and fifteen healthy dogs were included as controls. Diagnosis of babesiosis was confirmed by polymerase chain reaction and reverse line blot. Blood samples were collected from the jugular vein at admission, prior to any treatment. Cytokine concentrations were assessed using a canine-specific multiplex assay on an automated analyser. Serum concentrations of interleukin (IL)-2, IL-6, IL-8, IL-10, IL-18, granulocyte-macrophage colony stimulating factor (GM-CSF) and monocyte chemotactic protein-1 (MCP-1) were measured. Twelve of the Babesia-infected dogs died (12%) and 85 survived (88%). Babesia-infected dogs were also divided into those that presented within 48 hours from displaying clinical signs, and those that presented more than 48 hours after displaying clinical signs. Cytokine concentrations were compared between the different groups using the Mann-Whitney U test. IL-10 and MCP-1 concentrations were significantly elevated for the Babesia-infected dogs compared to the healthy controls. In contrast, the IL-8 concentration was significantly decreased in the Babesia-infected dogs compared to the controls. Concentrations of IL-6 and MCP-1 were significantly increased in the non-survivors compared to the survivors. Concentrations for IL-2, IL-6, IL-18 and GM-CSF were significantly higher in those cases that presented during the more acute stage of the disease. These findings suggest that a mixed cytokine response is present in dogs with babesiosis caused by B. rossi, and that an excessive pro-inflammatory response may result in a poor outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.