ArticlePloS one2016
Seasonally Changing Cryptochrome 1b Expression in the Retinal Ganglion Cells of a Migrating Passerine Bird.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Genetic analysis of cryptochrome in insect magnetosensitivity.Frontiers in physiology · 2022Pooled it
- Splicing of a core circadian clock gene regulates seasonal adaptations by a winter gating mechanism.Science advances · 2026Article
- Structure of European robin cryptochrome 1 reveals a role in circadian rhythms, not magnetoreception.iScience · 2025Article
- Protein and Solvent Reorganization Drives Radical Pair Stability in Avian Cryptochrome 4a.Journal of the American Chemical Society · 2025Article
- Splicing of a core clock gene regulates seasonal adaptations by a winter gating mechanism.bioRxiv : the preprint server for biology · 2025Article
- Cryptochrome 4b protein is probably irrelevant for radical pair-based magnetoreception in the European robin.Journal of the Royal Society, Interface · 2025Article
- European Robin Cryptochrome-4a Associates with Lipid Bilayers in an Ordered Manner, Fulfilling a Molecular-Level Condition for Magnetoreception.ACS chemical biology · 2025Article
- Dimerization of European Robin Cryptochrome 4a.The journal of physical chemistry. B · 2023Article
- Upper bound for broadband radiofrequency field disruption of magnetic compass orientation in night-migratory songbirds.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Double cones in the avian retina form an oriented mosaic which might facilitate magnetoreception and/or polarized light sensing.Journal of the Royal Society, Interface · 2022Article
- Localisation of cryptochrome 2 in the avian retina.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2022Article
- Broadband 75-85 MHz radiofrequency fields disrupt magnetic compass orientation in night-migratory songbirds consistent with a flavin-based radical pair magnetoreceptor.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2022Article
- Cryptochrome magnetoreception: four tryptophans could be better than three.Journal of the Royal Society, Interface · 2021Article
- Cryptochrome expression in avian UV cones: revisiting the role of CRY1 as magnetoreceptor.Scientific reports · 2021Article
- The Magnetic Compass of Birds: The Role of Cryptochrome.Frontiers in physiology · 2021Review
- A novel isoform of cryptochrome 4 (Cry4b) is expressed in the retina of a night-migratory songbird.Scientific reports · 2020Article
- Protein-protein interaction of the putative magnetoreceptor cryptochrome 4 expressed in the avian retina.Scientific reports · 2020Article
- Article
- Magnetoreception in birds.Journal of the Royal Society, Interface · 2019Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cryptochromes, blue-light absorbing proteins involved in the circadian clock, have been proposed to be the receptor molecules of the avian magnetic compass. In birds, several cryptochromes occur: Cryptochrome 2, Cryptochrome 4 and two splice products of Cryptochrome 1, Cry1a and Cry1b. With an antibody not distinguishing between the two splice products, Cryptochrome 1 had been detected in the retinal ganglion cells of garden warblers during migration. A recent study located Cry1a in the outer segments of UV/V-cones in the retina of domestic chickens and European robins, another migratory species. Here we report the presence of cryptochrome 1b (eCry1b) in retinal ganglion cells and displaced ganglion cells of European Robins, Erithacus rubecula. Immuno-histochemistry at the light microscopic and electron microscopic level showed eCry1b in the cell plasma, free in the cytosol as well as bound to membranes. This is supported by immuno-blotting. However, this applies only to robins in the migratory state. After the end of the migratory phase, the amount of eCry1b was markedly reduced and hardly detectable. In robins, the amount of eCry1b in the retinal ganglion cells varies with season: it appears to be strongly expressed only during the migratory period when the birds show nocturnal migratory restlessness. Since the avian magnetic compass does not seem to be restricted to the migratory phase, this seasonal variation makes a role of eCry1b in magnetoreception rather unlikely. Rather, it could be involved in physiological processes controlling migratory restlessness and thus enabling birds to perform their nocturnal flights.
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