ArticlePloS one2016
Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 79 citations in OpenAlex.
- Review
- Thyroid hormone deprivation creates an immunological signature in the mouse liver, involving Kupffer cell presentation as the mouse ages.Endocrine · 2026Article
- DNA Damage and Repair in Thyroid Physiology and Disease.Endocrine reviews · 2026Review
- Beyond hormone deficiency: a framework for endocrine-immune-niche integration in aging skeletal muscle regeneration.Frontiers in immunology · 2026Review
- Phenotypic Age Acceleration as a Mediator in Thyroid Hormone-Related Cardiovascular Risk Among the Elderly.Cardiology research and practice · 2026Article
- Thyroid dysfunction in ageing populations.Endocrine connections · 2025Review
- Causal associations between thyroid function and sarcopenia-related traits: a Mendelian randomization study.Hormones (Athens, Greece) · 2025Article
- Review
- Assessing thyroid health: phenotypic age compared to chronological age.Frontiers in endocrinology · 2025Article
- The ageing thyroid: implications for longevity and patient care.Nature reviews. Endocrinology · 2024Review
- Cardiac recovery from pressure overload is not altered by thyroid hormone status in old mice.Frontiers in endocrinology · 2024Article
- Decreased hepatic thyroid hormone signaling in systemic and liver-specific but not brain-specific accelerated aging due to DNA repair deficiency in mice.European thyroid journal · 2023Article
- Age-Related Hormones Changes and Its Impact on Health Status and Lifespan.Aging and disease · 2023Review
- Age-related variation in thyroid function - a narrative review highlighting important implications for research and clinical practice.Thyroid research · 2023Review
- Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study.GeroScience · 2021Article
- Murine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging.Genome research · 2019Article
- Age-Related Resistance to Thyroid Hormone Action.Drugs & aging · 2019Review
- Thyroid Hormones in the Brain and Their Impact in Recovery Mechanisms After Stroke.Frontiers in neurology · 2019Review
- Reduced expression of thyroid hormone receptor β in human nonalcoholic steatohepatitis.Endocrine connections · 2018Article
- Inactivation of hepatic ATRX inAging · 2018Article
Corrections and comments
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Authors and funding
27 authors at 9 institutions in 4 countries.
Funding
Abstract
DNA damage contributes to the process of aging, as underscored by premature aging syndromes caused by defective DNA repair. Thyroid state changes during aging, but underlying mechanisms remain elusive. Since thyroid hormone (TH) is a key regulator of metabolism, changes in TH signaling have widespread effects. Here, we reveal a significant common transcriptomic signature in livers from hypothyroid mice, DNA repair-deficient mice with severe (Csbm/m/Xpa-/-) or intermediate (Ercc1-/Δ-7) progeria and naturally aged mice. A strong induction of TH-inactivating deiodinase D3 and decrease of TH-activating D1 activities are observed in Csbm/m/Xpa-/- livers. Similar findings are noticed in Ercc1-/Δ-7, in naturally aged animals and in wild-type mice exposed to a chronic subtoxic dose of DNA-damaging agents. In contrast, TH signaling in muscle, heart and brain appears unaltered. These data show a strong suppression of TH signaling in specific peripheral organs in premature and normal aging, probably lowering metabolism, while other tissues appear to preserve metabolism. D3-mediated TH inactivation is unexpected, given its expression mainly in fetal tissues. Our studies highlight the importance of DNA damage as the underlying mechanism of changes in thyroid state. Tissue-specific regulation of deiodinase activities, ensuring diminished TH signaling, may contribute importantly to the protective metabolic response in aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.