ArticleJournal of neurotrauma2017
Cyclic Head Rotations Produce Modest Brain Injury in Infant Piglets.
Article in Journal of neurotrauma, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Modeling of inflicted head injury by shaking trauma in children: what can we learn? : Update to parts I&II: A systematic review of animal, mathematical and physical models.Forensic science, medicine, and pathology · 2025Pooled it
- Modeling of inflicted head injury by shaking trauma in children: what can we learn? : Part I: A systematic review of animal models.Forensic science, medicine, and pathology · 2019Pooled it
- Frequency-Dependent Amplification of Head Motion in Infant Rockers: A Segmental IMU-Based Signal Analysis.Journal of clinical medicine · 2025Article
- Rapid Amplification of Cerebrospinal Fluid Pressure as a Possible Mechanism for Optic Nerve Sheath Bleeding in Infants With Nonaccidental Head Injury.Investigative ophthalmology & visual science · 2024Article
- Developing a porcine model of severe traumatic brain injury induced by high amplitude rotational acceleration.Brain & spine · 2024Article
- Altered Auditory and Visual Evoked Potentials following Single and Repeated Low-Velocity Head Rotations in 4-Week-Old Swine.Biomedicines · 2023Article
- New Insights into the Diagnosis and Age Determination of Retinal Hemorrhages from Abusive Head Trauma: A Systematic Review.Diagnostics (Basel, Switzerland) · 2023Review
- Non-accidental injury in children-a sub-Saharan perspective on a multidisciplinary, co-ordinated care approach.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Abusive Head Trauma Animal Models: Focus on Biomarkers.International journal of molecular sciences · 2023Review
- Animal models of pediatric abusive head trauma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Review
- Multiple Head Rotations Result in Persistent Gait Alterations in Piglets.Biomedicines · 2022Article
- Exploring the Vitreoretinal Interface: A Key Instigator of Unique Retinal Hemorrhage Patterns in Pediatric Head Trauma.Korean journal of ophthalmology : KJO · 2022Article
- Roadmap for Advancing Pre-Clinical Science in Traumatic Brain Injury.Journal of neurotrauma · 2021Review
- MR Imaging of Human Brain Mechanics In Vivo: New Measurements to Facilitate the Development of Computational Models of Brain Injury.Annals of biomedical engineering · 2021Review
- A perfect storm: The distribution of tissue damage depends on seizure duration, hemorrhage, and developmental stage in a gyrencephalic, multi-factorial, severe traumatic brain injury model.Neurobiology of disease · 2021Article
- Reproducibility and Characterization of Head Kinematics During a Large Animal Acceleration Model of Traumatic Brain Injury.Frontiers in neurology · 2021Article
- Predictions of neonatal porcine bridging vein rupture and extra-axial hemorrhage during rapid head rotations.Journal of the mechanical behavior of biomedical materials · 2020Article
- Development of a Model of Hemispheric Hypodensity ("Big Black Brain").Journal of neurotrauma · 2019Article
- Pathophysiological and behavioral deficits in developing mice following rotational acceleration-deceleration traumatic brain injury.Disease models & mechanisms · 2018Article
- Failure and Fatigue Properties of Immature Human and Porcine Parasagittal Bridging Veins.Annals of biomedical engineering · 2017Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Repetitive back-and-forth head rotation from vigorous shaking is purported to be a central mechanism responsible for diffuse white matter injury, subdural hemorrhage, and retinal hemorrhage in some cases of abusive head trauma (AHT) in young children. Although animal studies have identified mechanisms of traumatic brain injury (TBI) associated with single rapid head acceleration-decelerations at levels experienced in a motor vehicle crash, few experimental studies have investigated TBI from repetitive head rotations. The objective of this study was to systematically investigate the post-injury pathological time-course after cyclic, low-velocity head rotations in the piglet and compare them with single head rotations. Injury metrics were the occurrence and extent of axonal injury (AI), extra-axial hemorrhage (EAH), red cell neuronal/axonal change (RCNAC), and ocular injury (OI). Hyperflexion/extension of the neck were purposefully avoided in the study, resulting in unscaled angular accelerations at the lower end of reported infant surrogate shaking kinematics. All findings were at the mild end of the injury spectrum, with no significant findings at 6 h post-injury. Cyclic head rotations, however, produced modest AI that significantly increased with time post-injury (p < 0.035) and had significantly greater amounts of RCNAC and EAH than noncyclic head rotations after 24 h post-injury (p < 0.05). No OI was observed. Future studies should investigate the contributions of additional physiological and mechanical features associated with AHT (e.g., hyperflexion/extension, increased intracranial pressure from crying or thoracic compression, and more than two cyclic episodes) to enhance our understanding of the causality between proposed mechanistic factors and AHT in infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.