ArticleAntimicrobial agents and chemotherapy2016
Antitrypanosomal Activities and Mechanisms of Action of Novel Tetracyclic Iridoids from Morinda lucida Benth.
Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Metabolomic profile, anti-trypanosomal potential and molecular docking studies ofJournal of enzyme inhibition and medicinal chemistry · 2023Article
- Plant Terpenoids as Hit Compounds against Trypanosomiasis.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Revisiting nature: a review of iridoids as a potential antileishmanial class.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2022Review
- In Vitro Mechanism of Action ofAdvances in pharmacological and pharmaceutical sciences · 2022Article
- QSAR Modeling for Multi-Target Drug Discovery: Designing Simultaneous Inhibitors of Proteins in Diverse Pathogenic Parasites.Frontiers in chemistry · 2021Article
- Synthesis, Structure and In Vitro Anti-Trypanosomal Activity of Non-Toxic Arylpyrrole-Based Chalcone Derivatives.Molecules (Basel, Switzerland) · 2020Article
- Cinnamoyl-Oxaborole Amides: Synthesis and Their in Vitro Biological Activity.Molecules (Basel, Switzerland) · 2018Article
- Medicinal Plants Used in the Treatment of Mental and Neurological Disorders in Ghana.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Novel lead compounds in pre-clinical development against African sleeping sickness.MedChemComm · 2017Review
- In vitro anti-Leishmania activity of tetracyclic iridoids from Morinda lucida, benth.Tropical medicine and health · 2016Article
- In vitro fertilization using sperm activated by ML-2-3 isolated fromReproductive medicine and biologyArticle
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Authors and funding
27 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trypanosoma brucei parasites are kinetoplastid protozoa that devastate the health and economic well-being of millions of people in Africa through the disease human African trypanosomiasis (HAT). New chemotherapy has been eagerly awaited due to severe side effects and the drug resistance issues plaguing current drugs. Recently, there has been an emphasis on the use of medicinal plants worldwide. Morinda lucida Benth. is a popular medicinal plant widely distributed in Africa, and several research groups have reported on the antiprotozoal activities of this plant. In this study, we identified three novel tetracyclic iridoids, molucidin, ML-2-3, and ML-F52, from the CHCl3 fraction of M. lucida leaves, which possess activity against the GUTat 3.1 strain of T. brucei brucei The 50% inhibitory concentrations (IC50) of molucidin, ML-2-3, and ML-F52 were 1.27 μM, 3.75 μM, and 0.43 μM, respectively. ML-2-3 and ML-F52 suppressed the expression of paraflagellum rod protein subunit 2, PFR-2, and caused cell cycle alteration, which preceded apoptosis induction in the bloodstream form of Trypanosoma parasites. Novel tetracyclic iridoids may be promising lead compounds for the development of new chemotherapies for African trypanosomal infections in humans and animals.
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