ArticleNature communications2016
A ligand-independent integrin β1 mechanosensory complex guides spindle orientation.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Spindle Orientation Regulation Is Governed by Redundant Cortical Mechanosensing and Shape-Sensing Mechanisms.International journal of molecular sciences · 2025Article
- Microtubule regulation in cancer cells.Frontiers in cell and developmental biology · 2025Article
- Epigenetic regulation of asymmetric cell division by the LIBR-BRD4 axis.Nucleic acids research · 2024Article
- Mechanosensory entities and functionality of endothelial cells.Frontiers in cell and developmental biology · 2024Review
- Mitotic outcomes and errors in fibrous environments.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Mechanical Stretch Induced Skin Regeneration: Molecular and Cellular Mechanism in Skin Soft Tissue Expansion.International journal of molecular sciences · 2022Review
- Review
- Stem-like T cells and niches: Implications in human health and disease.Frontiers in immunology · 2022Review
- Overexpression ofInternational journal of molecular sciences · 2021Article
- FAK displacement from focal adhesions: a promising strategy to target processes implicated in cancer progression and metastasis.Cell communication and signaling : CCS · 2021Article
- Limitation in Controlling the Morphology of Mammalian Vero Cells Induced by Cell Division on Asymmetric Tungsten-Silicon Oxide Nanocomposite.Materials (Basel, Switzerland) · 2020Article
- Mechanical stretching stimulates growth of the basal layer and rete ridges in the epidermis.Journal of tissue engineering and regenerative medicine · 2019Article
- Connections between the cell cycle, cell adhesion and the cytoskeleton.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- β1 integrin is a sensor of blood flow direction.Journal of cell science · 2019Article
- A simple mechanochemical model for calcium signalling in embryonic epithelial cells.Journal of mathematical biology · 2019Article
- The balance between adhesion and contraction during cell division.Current opinion in cell biology · 2019Review
- Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis.Nature cell biology · 2018Article
- Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Multiscale force sensing in development.Nature cell biology · 2017Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Control of spindle orientation is a fundamental process for embryonic development, morphogenesis and tissue homeostasis, while defects are associated with tumorigenesis and other diseases. Force sensing is one of the mechanisms through which division orientation is determined. Here we show that integrin β1 plays a critical role in this process, becoming activated at the lateral regions of the cell cortex in a ligand-independent manner. This activation is force dependent and polar, correlating with the spindle capture sites. Inhibition of integrin β1 activation on the cortex and disruption of its asymmetric distribution leads to spindle misorientation, even when cell adhesion is β1 independent. Examining downstream targets reveals that a cortical mechanosensory complex forms on active β1, and regulates spindle orientation irrespective of cell context. We propose that ligand-independent integrin β1 activation is a conserved mechanism that allows cell responses to external stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.