Evidence map›Paper›PMID 26952285›Full record

ReviewWiley interdisciplinary reviews. Systems biology and medicine2016

Mathematical modeling of cardiac growth and remodeling.

L C Lee, G S Kassab, J M Guccione

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Systems biology and medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Mathematical Descriptions of Damage to Cells and Tissues Following Heating.Advances in experimental medicine and biology · 2026
    Article
  3. Article
  4. Article
  5. Global Sensitivity Analysis of a Novel Signaling Network for Heart Growth With Local IGF1 Production.International journal for numerical methods in biomedical engineering · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
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  12. Review
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  15. Review
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

L C LeeDepartment of Mechanical Engineering, Michigan State University, East Lansing, MI, USA.
G S KassabCalifornia Medical Innovations Institute, San Diego, CA, USA.
J M GuccioneDepartment of Surgery, University of California at San Francisco, San Francisco, CA, USA.

Funding

Multi-Scale Laws of Myocardial Growth and RemodelingU01HL119578 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUCCIONE, JULIUS MATTEO, KASSAB, GHASSAN S · 2014 to 2018
$3.8M
VIRTUAL TOOLS FOR CARDIAC VENTRICULAR REMODELING SURGERYR01HL077921 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUCCIONE, JULIUS MATTEO · 2006 to 2015
$3.4M
Minimally Invasive Ventricular Polymeric Injection for Treatment of Heart FailureR01HL118627 · NHLBI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI GUCCIONE, JULIUS MATTEO, KASSAB, GHASSAN S · 2013 to 2016
$3.0M
NHLBI NIH HHS R01 HL077921NHLBI NIH HHS R01 HL118627NHLBI NIH HHS U01 HL119578
6 · The paper itself

Abstract

This review provides an overview of the current state of mathematical models of cardiac growth and remodeling (G&R). We concisely describe the experimental observations associated with cardiac G&R and discuss existing mathematical models that describe this process. To facilitate the discussion, we have organized the G&R models in terms of (1) the physical focus (biochemical vs mechanical) and (2) the process that they describe (myocyte hypertrophy vs extracellular matrix remodeling). The review concludes with a discussion of some possible directions that can advance the existing state of cardiac G&R mathematical modeling. WIREs Syst Biol Med 2016, 8:211-226. doi: 10.1002/wsbm.1330 For further resources related to this article, please visit the WIREs website.

Indexed as

Models, TheoreticalVentricular RemodelingCardiac Resynchronization TherapyExtracellular MatrixHeart DiseasesHeart VentriclesHumansMyocardium

Identifiers

PMID26952285
PMCPMC4841715

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.