ArticleJournal of the American Chemical Society2016
Direct Catalytic Asymmetric Mannich Reactions for the Construction of Quaternary Carbon Stereocenters.
Article in Journal of the American Chemical Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- PotassiumChemical science · 2025Article
- Dinuclear Zn-Catalytic System as Brønsted Base and Lewis Acid for Enantioselectivity in Same Chiral Environment.ACS omega · 2024Review
- Multicomponent double Mannich alkylamination involving C(spNature communications · 2022Article
- Asymmetric construction of acyclic quaternary stereocenters via direct enantioselective additions of α-alkynyl ketones to allenamides.Nature communications · 2021Article
- Recent advances and prospects in the Zn-catalysed Mannich reaction.RSC advances · 2021Review
- Development of bifunctional organocatalysts and application to asymmetric total synthesis of naucleofficine I and II.Nature communications · 2019Article
- Organocatalytic Enantioselective Mannich Reaction: Direct Access to Chiral β-Amino Esters.ACS omega · 2019Article
- Organocatalytic sulfa-Michael/aldol cascade: constructing functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter.RSC advances · 2018Article
- C-H Functionalization of Amines via Alkene-Derived Nucleophiles through Cooperative Action of Chiral and Achiral Lewis Acid Catalysts: Applications in Enantioselective Synthesis.Journal of the American Chemical Society · 2018Article
- Mechanism and rate constant of proline-catalysed asymmetric aldol reaction of acetone and p-nitrobenzaldehyde in solution medium: Density-functional theory computation.Journal of advanced research · 2018Article
- Direct catalytic enantioselective amination of ketones for the formation of tri- and tetrasubstituted stereocenters.Chemical science · 2018Article
- Controlling Regioselectivity in the Enantioselective N-Alkylation of Indole Analogues Catalyzed by Dinuclear Zinc-ProPhenol.Angewandte Chemie (International ed. in English) · 2017Article
- Efficient Access to Chiral Trisubstituted Aziridines via Catalytic Enantioselective Aza-Darzens Reactions.Angewandte Chemie (International ed. in English) · 2017Article
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3 authors.
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Abstract
Herein, we report a Zn-ProPhenol catalyzed Mannich reaction using α-branched ketones as nucleophilic partners for the direct enantio- and diastereoselective construction of quaternary carbon stereocenters. The reaction can be run on a gram-scale with a low catalyst loading without impacting its efficiency. Moreover, the Mannich adducts can be further elaborated with complete diastereocontrol to access molecules possessing complex stereotriads.
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