Observational studyThe Journal of pediatrics2016
Unbound Bilirubin and Auditory Neuropathy Spectrum Disorder in Late Preterm and Term Infants with Severe Jaundice.
Observational study in The Journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Biological markers of hearing loss in neonates admitted to the neonatal intensive care unit: a systematic review and meta-analysis.Frontiers in neuroscience · 2026Pooled it
- Is auditory neuropathy an appropriate term? A systematic literature review on its aetiology and pathogenesis.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2021Pooled it
- Cochlear implantation for sensorineural hearing loss caused by neonatal hyperbilirubinemia.Seminars in perinatology · 2026Review
- Label-Free Quantification of Bilirubin Using a Refractive Index-Insensitive Nanolaminate SERS Substrate.Biosensors · 2026Article
- Unbound bilirubin and bilirubin-albumin binding levels of Japanese neonates.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Clinical and genetic risk factors associated with neonatal severe hyperbilirubinemia: a case-control study based on the China Neonatal Genomes Project.Frontiers in genetics · 2023Article
- A Study of JCIH (Joint Commission on Infant Hearing) Risk Factors for Hearing Loss in Babies of NICU and Well Baby Nursery at a Tertiary Care Center.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- High levels of unbound bilirubin are associated with acute bilirubin encephalopathy in post-exchange transfusion neonates.Italian journal of pediatrics · 2021Article
- Early prediction of adverse outcomes in infants with acute bilirubin encephalopathy.Annals of clinical and translational neurology · 2020Article
- Article
- Developmental influence of unconjugated hyperbilirubinemia and neurobehavioral disorders.Pediatric research · 2019Review
- High unbound bilirubin for age: a neurotoxin with major effects on the developing brain.Pediatric research · 2019Review
- Bilirubin Albumin Binding and Unbound Unconjugated Hyperbilirubinemia in Premature Infants.The Journal of pediatrics · 2018Observational
- Chronic Auditory Toxicity in Late Preterm and Term Infants With Significant Hyperbilirubinemia.Pediatrics · 2017Observational
- Auditory toxicity in late preterm and term neonates with severe jaundice.Developmental medicine and child neurology · 2017Article
- A Hypothesis for Using Pathway Genetic Load Analysis for Understanding Complex Outcomes in Bilirubin Encephalopathy.Frontiers in neuroscience · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThis study evaluates whether unbound bilirubin is a better predictor of auditory neuropathy spectrum disorder (ANSD) than total serum bilirubin (TSB) or the bilirubin:albumin molar ratio (BAMR) in late preterm and term neonates with severe jaundice (TSB ≥20 mg/dL or TSB that met exchange transfusion criteria). STUDY
designInfants ≥34 weeks' gestation with severe jaundice during the first 2 weeks of life were eligible for the prospective observational study. A comprehensive auditory evaluation was performed within 72 hours of peak TSB. ANSD was defined as absent or abnormal auditory brainstem evoked response waveform morphology at 80-decibel click intensity in the presence of normal outer hair cell function. TSB, serum albumin, and unbound bilirubin were measured using the colorimetric, bromocresol green, and modified peroxidase method, respectively.
resultsFive of 44 infants developed ANSD. By logistic regression, peak unbound bilirubin but not peak TSB or peak BAMR was associated with ANSD (OR, 4.6; 95% CI, 1.6-13.5; P = .002). On comparing receiver operating characteristic curves, the area under the curve for unbound bilirubin (0.92) was significantly greater (P = .04) compared with the area under the curve for TSB (0.50) or BAMR (0.62).
conclusionsUnbound bilirubin is a more sensitive and specific predictor of ANSD than TSB or BAMR in late preterm and term infants with severe jaundice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.