Evidence map›Paper›PMID 26951772›Full record

Trial reportThe British journal of ophthalmology2016

Randomised controlled trial of video clips and interactive games to improve vision in children with amblyopia using the I-BiT system.

Nicola Herbison, Daisy MacKeith, Anthony Vivian, Jon Purdy, Apostolos Fakis, Isabel M Ash, Sue V Cobb, Richard M Eastgate, Stephen M Haworth, Richard M Gregson and 1 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The British journal of ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01702727 (Evaluation and Development of a Novel Binocular Treatment), which is not on this map. Cited by 53 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 10 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01702727 phase2completednot on this map

Evaluation and Development of a Novel Binocular Treatment (I-BiTTM) System Using Video Clips and Interactive Games to Improve Vision in Children With Amblyopia ('Lazy Eye').

TypeinterventionalSponsorNottingham University Hospitals NHS TrustRan2012 to 2013Enrolled75ConditionsAmblyopiaArmsI-BiTTM game, Non-I-BiTTM game, I-BiTTM DVD
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 10 syntheses or guidelines pooled it, 112 citations in OpenAlex.

  1. Pooled it
  2. Interventions for improving adherence to amblyopia treatments in children.The Cochrane database of systematic reviews · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Occlusion for stimulus deprivation amblyopia.The Cochrane database of systematic reviews · 2020
    Pooled it
  10. Pooled it
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Nicola HerbisonDepartment of Ophthalmology, Nottingham University Hospitals, Nottingham, UK.
Daisy MacKeithDepartment of Ophthalmology, Addenbrooke's Hospital, Cambridge, UK.
Anthony VivianDepartment of Ophthalmology, Addenbrooke's Hospital, Cambridge, UK.
Jon PurdyDepartment of Computer Science, University of Hull, Hull, UK.
Apostolos FakisDerby Clinical Trials Unit, College of Health and Social Care, University of Derby, Derby, UK.
Isabel M AshDepartment of Ophthalmology, Nottingham University Hospitals, Nottingham, UK.
Sue V CobbDepartment of Mechanical, Materials and Manufacturing Engineering, University of Nottingham, Nottingham, UK.
Richard M EastgateDepartment of Mechanical, Materials and Manufacturing Engineering, University of Nottingham, Nottingham, UK.
Stephen M HaworthDepartment of Ophthalmology, Nottingham University Hospitals, Nottingham, UK.
Richard M GregsonDepartment of Ophthalmology, Nottingham University Hospitals, Nottingham, UK.
Alexander Je FossDepartment of Ophthalmology, Nottingham University Hospitals, Nottingham, UK.
Nottingham University Hospitals NHS Trust · GBAddenbrooke's Hospital · GBUniversity of Nottingham · GBUniversity of Derby · GBUniversity of Hull · GB

Funding

Department of Health II-LB-0813-20006Wellcome Trust
6 · The paper itself

Abstract

backgroundTraditional treatment of amblyopia involves either wearing a patch or atropine penalisation of the better eye. A new treatment is being developed on the basis of virtual reality technology allowing either DVD footage or computer games which present a common background to both eyes and the foreground, containing the imagery of interest, only to the amblyopic eye.

methodsA randomised control trial was performed on patients with amblyopia aged 4-8 years with three arms. All three arms had dichoptic stimulation using shutter glass technology. One arm had DVD footage shown to the amblyopic eye and common background to both, the second used a modified shooter game, Nux, with sprite and targets presented to the amblyopic eye (and background to both) while the third arm had both background and foreground presented to both eyes (non-interactive binocular treatment (non-I-BiT) games).

resultsSeventy-five patients were randomised; 67 were residual amblyopes and 70 had an associated strabismus. The visual acuity improved in all three arms by approximately 0.07 logMAR in the amblyopic eye at 6 weeks. There was no difference between I-BiT DVD and non-I-BiT games compared with I-BiT games (stated primary outcome) in terms of gain in vision.

conclusionsThere was a modest vision improvement in all three arms. Treatment was well tolerated and safe. There was no difference between the three treatments in terms of primary stated outcomes but treatment duration was short and the high proportion of previously treated amblyopia and strabismic amblyopia disadvantaged dichoptic stimulation treatment. TRIAL REGISTRATION NUMBER: NCT01702727, results.

Indexed as

Videodisc RecordingVideo GamesVisual AcuityAmblyopiaChildChild, PreschoolComputer GraphicsEquipment DesignFemaleFollow-Up StudiesHumansMalePhotic StimulationSensory DeprivationStrabismusTime FactorsChild health (paediatrics)Treatment otherVision

Identifiers

PMID26951772
PMCPMC5136691
OpenAlexW2295555304

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.