ArticleProceedings of the National Academy of Sciences of the United States of America2016
Focal expression of mutant huntingtin in the songbird basal ganglia disrupts cortico-basal ganglia networks and vocal sequences.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 45 citations in OpenAlex.
- Alpha-synuclein overexpression reduces neural activity within a basal ganglia vocal nucleus in a zebra finch model.PloS one · 2026Article
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- An anatomical substrate of credit assignment in reinforcement learning.bioRxiv : the preprint server for biology · 2025Article
- Syllable as a Synchronization Mechanism That Makes Human Speech Possible.Brain sciences · 2024Article
- Article
- Partial inactivation of songbird auditory cortex impairs both tempo and pitch discrimination.Molecular brain · 2023Article
- Reversible inhibition of the basal ganglia prolongs repetitive vocalization but only weakly affects sequencing at branch points in songbirds.Cerebral cortex communications · 2023Article
- Plasticity of stereotyped birdsong driven by chronic manipulation of cortical-basal ganglia activity.Current biology : CB · 2021Article
- Expression of FoxP2 in the basal ganglia regulates vocal motor sequences in the adult songbird.Nature communications · 2021Article
- Variable but not random: temporal pattern coding in a songbird brain area necessary for song modification.Journal of neurophysiology · 2021Article
- What Is the Role of Thalamostriatal Circuits in Learning Vocal Sequences?Frontiers in neural circuits · 2021Article
- The stressed brain: regional and stress-related corticosterone and stress-regulated gene expression in the adult zebra finch (Taeniopygia guttata).Journal of neuroendocrinology · 2020Article
- Manipulations of inhibition in cortical circuitry differentially affect spectral and temporal features of Bengalese finch song.Journal of neurophysiology · 2020Article
- The Avian Basal Ganglia Are a Source of Rapid Behavioral Variation That Enables Vocal Motor Exploration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Article
- Avian genomics lends insights into endocrine function in birds.General and comparative endocrinology · 2018Review
- To transduce a zebra finch: interrogating behavioral mechanisms in a model system for speech.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Review
- Advantages of comparative studies in songbirds to understand the neural basis of sensorimotor integration.Journal of neurophysiology · 2017Review
- Overexpression of human NR2B receptor subunit in LMAN causes stuttering and song sequence changes in adult zebra finches.Scientific reports · 2017Article
- Social context differentially modulates activity of two interneuron populations in an avian basal ganglia nucleus.Journal of neurophysiology · 2016Article
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4 authors at 3 institutions in 1 country.
Funding
Abstract
The basal ganglia (BG) promote complex sequential movements by helping to select elementary motor gestures appropriate to a given behavioral context. Indeed, Huntington's disease (HD), which causes striatal atrophy in the BG, is characterized by hyperkinesia and chorea. How striatal cell loss alters activity in the BG and downstream motor cortical regions to cause these disorganized movements remains unknown. Here, we show that expressing the genetic mutation that causes HD in a song-related region of the songbird BG destabilizes syllable sequences and increases overall vocal activity, but leave the structure of individual syllables intact. These behavioral changes are paralleled by the selective loss of striatal neurons and reduction of inhibitory synapses on pallidal neurons that serve as the BG output. Chronic recordings in singing birds revealed disrupted temporal patterns of activity in pallidal neurons and downstream cortical neurons. Moreover, reversible inactivation of the cortical neurons rescued the disorganized vocal sequences in transfected birds. These findings shed light on a key role of temporal patterns of cortico-BG activity in the regulation of complex motor sequences and show how a genetic mutation alters cortico-BG networks to cause disorganized movements.
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