ArticleEMBO reports2016
Sororin loads to the synaptonemal complex central region independently of meiotic cohesin complexes.
Article in EMBO reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 29 citations in OpenAlex.
- The synaptonemal complex: structure, function, and clinical implications†.Biology of reproduction · 2026Article
- Chromosome Architecture Defined by the Meiosis-Specific Cohesin in Mammalian Germ Cells.Advances in experimental medicine and biology · 2026Review
- The Organotypic Culture of Mouse Seminiferous Tubules as a Reliable Methodology for the Study of Meiosis In Vitro.Methods in molecular biology (Clifton, N.J.) · 2024Article
- MicroRNA-202 safeguards meiotic progression by preventing premature SEPARASE-mediated REC8 cleavage.EMBO reports · 2022Article
- The cohesin stabilizer Sororin drives GScience advances · 2021Article
- Chromosome Organization in Early Meiotic Prophase.Frontiers in cell and developmental biology · 2021Review
- Meiotic Chromosome Dynamics in Zebrafish.Frontiers in cell and developmental biology · 2021Review
- Critical Functions of PP2A-Like Protein Phosphotases in Regulating Meiotic Progression.Frontiers in cell and developmental biology · 2021Review
- Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.Journal of cell science · 2020Article
- In Vitro Meiosis of Male Germline Stem Cells.Stem cell reports · 2020Article
- PDS5 proteins regulate the length of axial elements and telomere integrity during male mouse meiosis.EMBO reports · 2020Article
- Multivalent weak interactions between assembly units drive synaptonemal complex formation.The Journal of cell biology · 2020Article
- Is age-related increase of chromosome segregation errors in mammalian oocytes caused by cohesin deterioration?Reproductive medicine and biology · 2020Review
- The diagnostic and prognostic value of cell division cycle associated gene family in Hepatocellular Carcinoma.Journal of Cancer · 2020Article
- SWITCH 1/DYAD is a WINGS APART-LIKE antagonist that maintains sister chromatid cohesion in meiosis.Nature communications · 2019Article
- The cohesin complex in mammalian meiosis.Genes to cells : devoted to molecular & cellular mechanisms · 2019Review
- Zipping and Unzipping: Protein Modifications Regulating Synaptonemal Complex Dynamics.Trends in genetics : TIG · 2018Review
- Article
- Preparation of Meiotic Chromosome Spreads from Mouse Spermatocytes.Journal of visualized experiments : JoVE · 2017Article
- Sororin is enriched at the central region of synapsed meiotic chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2017Article
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution and regulation of the cohesin complexes have been extensively studied during mitosis. However, the dynamics of their different regulators in vertebrate meiosis is largely unknown. In this work, we have analyzed the distribution of the regulatory factor Sororin during male mouse meiosis. Sororin is detected at the central region of the synaptonemal complex during prophase I, in contrast with the previously reported localization of other cohesin components in the lateral elements. This localization of Sororin depends on the transverse filaments protein SYCP1, but not on meiosis-specific cohesin subunits REC8 and SMC1β. By late prophase I, Sororin accumulates at centromeres and remains there up to anaphase II The phosphatase activity of PP2A seems to be required for this accumulation. We hypothesize that Sororin function at the central region of the synaptonemal complex could be independent on meiotic cohesin complexes. In addition, we suggest that Sororin participates in the regulation of centromeric cohesion during meiosis in collaboration with SGO2-PP2A.
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