ArticleNephron extra
A Higher Cardiothoracic Ratio Is Associated with 2-Year Mortality after Hemodialysis Initiation.
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Who cites it
11 citing papers in PubMed.
- Association between the Cardiothoracic Ratio on Chest X-rays and the Respiratory Function in Patients with Interstitial Lung Diseases: a Cross-sectional Study.Internal medicine (Tokyo, Japan) · 2025Article
- Evaluation of cardiothoracic ratio as a potential predictor of cardiovascular abnormalities in individuals with type II diabetes mellitus: a case-control study.Journal of medicine and life · 2024Article
- Correlations of sST2 and Gal-3 with Cardiothoracic Ratio in Patients with Chronic Kidney Disease.Biomedicines · 2024Article
- The Performance of a Deep Learning-Based Automatic Measurement Model for Measuring the Cardiothoracic Ratio on Chest Radiographs.Bioengineering (Basel, Switzerland) · 2023Article
- Validation of an Automated Cardiothoracic Ratio Calculation for Hemodialysis Patients.Diagnostics (Basel, Switzerland) · 2023Article
- A study on computed tomography cardiothoracic ratio in predicting left ventricular systolic dysfunction.Clinical and experimental emergency medicine · 2023Article
- Cardiothoracic ratio values and trajectories are associated with risk of requiring dialysis and mortality in chronic kidney disease.Communications medicine · 2023Article
- Neutralization Assessments Reveal High Cardiothoracic Ratio and Old Age as Independent Predictors of Low Neutralizing Antibody Titers in Hemodialysis Patients Receiving a Single Dose of COVID-19 Vaccine.Journal of personalized medicine · 2022Article
- Radiological Cardiothoracic Ratio as a Potential Marker of Left Ventricular Hypertrophy Assessed by Echocardiography.Radiology research and practice · 2022Article
- Radiological Cardiothoracic Ratio in Evidence-Based Medicine.Journal of clinical medicine · 2021Review
- Fluid and hemodynamic management in hemodialysis patients: challenges and opportunities.Jornal brasileiro de nefrologiaArticle
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Authors and funding
19 authors.
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Abstract
unlabelledA high cardiothoracic ratio (CTR) is indicative of a cardiac disorder. However, few reports have revealed an association between the CTR and mortality in patients starting hemodialysis (HD).
methodsPatients with HD initiation (n = 387; mean age, 66.7 ± 12.7 years) were divided into the following three groups according to their CTR at HD initiation: CTR <50%, 50% ≤ CTR < 55%, and CTR ≥55%. Kaplan-Meier analysis was performed to compare 2-year all-cause mortality among these groups. Furthermore, we investigated the factors affecting their 2-year mortality using a Cox proportional hazard regression analysis.
resultsSixty-five patients (17%) died within 2 years after HD initiation. Kaplan-Meier analysis showed that patients with CTR ≥55% had a higher mortality rate than those in the other groups. Cox proportional hazard regression analysis was performed using parameters with p values <0.1 among these three groups [sex, age, presence or absence of ischemic heart disease, hemoglobin levels, serum albumin levels, CTR, body mass index (BMI)] and confounding factors [presence or absence of diabetes mellitus, and estimated glomerular filtration rate (eGFR)]. Age, eGFR, BMI, and CTR ≥55% at HD initiation were identified as factors influencing 2-year mortality.
conclusionCTR >55% is one of the most important independent factors to affect 2-year all-cause mortality. Thus, confirming the cardiac condition of patients at HD initiation with a CTR >55% may improve their survival.
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