Evidence map›Paper›PMID 26951605›Full record

Observational studyCirculation. Cardiovascular imaging2016

HIV-1-Related Cardiovascular Disease Is Associated With Chronic Inflammation, Frequent Pericardial Effusions, and Probable Myocardial Edema.

Ntobeko Ntusi, Eoin O'Dwyer, Lucy Dorrell, Emma Wainwright, Stefan Piechnik, Genevieve Clutton, Gemma Hancock, Vanessa Ferreira, Pete Cox, Motasim Badri and 5 more

Registry-linked trialAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Circulation. Cardiovascular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04904406 (Changes in Weight and Body Composition After Switch to Dolutegravir/Lamivudine Compared to Continued Dolutegravir/Abacavir/Lamivudine for Virologically Suppressed HIV Infection), which is not on this map. Cited by 64 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 2 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04904406 phase4completednot on this mapstarted 2020, after this paper: background citation

Changes in Weight and Body Composition After Switch to Dolutegravir/Lamivudine Compared to Continued Dolutegravir/Abacavir/Lamivudine for Virologically Suppressed HIV Infection: A Randomized Open-label Superiority Trial: AVERTAS-1

TypeinterventionalSponsorThomas BenfieldRan2020 to 2023Enrolled81ConditionsHiv, HIV Infections, HIV Cardiomyopathy, Weight Change, BodyArmsDolutegravir / Lamivudine Oral Tablet
3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. HIV, HIV-Specific Factors, and Myocardial Disease in Women.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Multimodality Imaging in HIV-Associated Cardiovascular Complications: A Comprehensive Review.International journal of environmental research and public health · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Ntobeko NtusiFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom (N.N., S.P., V.F., T.K., S.N., C.H.); Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa (N.N., M.B.); Department of Cardiology, St.Vincent's Hospital, Darlinghurst, New South Wales, Australia (E.O., S.E., C.H.); Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia (E.O., S.E., C.H.); Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom (L.D., E.W., G.C., G.H.); Department of Physiology, Anatomy and Genetics (P.C., K.C., C.H.) and Oxford NIHR Biomedical Research Centre (S.N., C.H.), University of Oxford, Oxford, United Kingdom; and 1st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (T.K.).
Eoin O'DwyerFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom (N.N., S.P., V.F., T.K., S.N., C.H.); Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa (N.N., M.B.); Department of Cardiology, St.Vincent's Hospital, Darlinghurst, New South Wales, Australia (E.O., S.E., C.H.); Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia (E.O., S.E., C.H.); Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom (L.D., E.W., G.C., G.H.); Department of Physiology, Anatomy and Genetics (P.C., K.C., C.H.) and Oxford NIHR Biomedical Research Centre (S.N., C.H.), University of Oxford, Oxford, United Kingdom; and 1st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (T.K.).
Lucy DorrellFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom (N.N., S.P., V.F., T.K., S.N., C.H.); Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa (N.N., M.B.); Department of Cardiology, St.Vincent's Hospital, Darlinghurst, New South Wales, Australia (E.O., S.E., C.H.); Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia (E.O., S.E., C.H.); Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom (L.D., E.W., G.C., G.H.); Department of Physiology, Anatomy and Genetics (P.C., K.C., C.H.) and Oxford NIHR Biomedical Research Centre (S.N., C.H.), University of Oxford, Oxford, United Kingdom; and 1st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (T.K.).
Emma WainwrightFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom (N.N., S.P., V.F., T.K., S.N., C.H.); Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa (N.N., M.B.); Department of Cardiology, St.Vincent's Hospital, Darlinghurst, New South Wales, Australia (E.O., S.E., C.H.); Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia (E.O., S.E., C.H.); Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom (L.D., E.W., G.C., G.H.); Department of Physiology, Anatomy and Genetics (P.C., K.C., C.H.) and Oxford NIHR Biomedical Research Centre (S.N., C.H.), University of Oxford, Oxford, United Kingdom; and 1st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (T.K.).
Stefan PiechnikFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom (N.N., S.P., V.F., T.K., S.N., C.H.); Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa (N.N., M.B.); Department of Cardiology, St.Vincent's Hospital, Darlinghurst, New South Wales, Australia (E.O., S.E., C.H.); Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia (E.O., S.E., C.H.); Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom (L.D., E.W., G.C., G.H.); Department of Physiology, Anatomy and Genetics (P.C., K.C., C.H.) and Oxford NIHR Biomedical Research Centre (S.N., C.H.), University of Oxford, Oxford, United Kingdom; and 1st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (T.K.).
Genevieve CluttonFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom (N.N., S.P., V.F., T.K., S.N., C.H.); Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa (N.N., M.B.); Department of Cardiology, St.Vincent's Hospital, Darlinghurst, New South Wales, Australia (E.O., S.E., C.H.); Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia (E.O., S.E., C.H.); Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom (L.D., E.W., G.C., G.H.); Department of Physiology, Anatomy and Genetics (P.C., K.C., C.H.) and Oxford NIHR Biomedical Research Centre (S.N., C.H.), University of Oxford, Oxford, United Kingdom; and 1st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (T.K.).
Gemma HancockFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom (N.N., S.P., V.F., T.K., S.N., C.H.); Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa (N.N., M.B.); Department of Cardiology, St.Vincent's Hospital, Darlinghurst, New South Wales, Australia (E.O., S.E., C.H.); Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia (E.O., S.E., C.H.); Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom (L.D., E.W., G.C., G.H.); Department of Physiology, Anatomy and Genetics (P.C., K.C., C.H.) and Oxford NIHR Biomedical Research Centre (S.N., C.H.), University of Oxford, Oxford, United Kingdom; and 1st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (T.K.).
Vanessa FerreiraFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom (N.N., S.P., V.F., T.K., S.N., C.H.); Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa (N.N., M.B.); Department of Cardiology, St.Vincent's Hospital, Darlinghurst, New South Wales, Australia (E.O., S.E., C.H.); Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia (E.O., S.E., C.H.); Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom (L.D., E.W., G.C., G.H.); Department of Physiology, Anatomy and Genetics (P.C., K.C., C.H.) and Oxford NIHR Biomedical Research Centre (S.N., C.H.), University of Oxford, Oxford, United Kingdom; and 1st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (T.K.).
Pete CoxFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom (N.N., S.P., V.F., T.K., S.N., C.H.); Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa (N.N., M.B.); Department of Cardiology, St.Vincent's Hospital, Darlinghurst, New South Wales, Australia (E.O., S.E., C.H.); Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia (E.O., S.E., C.H.); Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom (L.D., E.W., G.C., G.H.); Department of Physiology, Anatomy and Genetics (P.C., K.C., C.H.) and Oxford NIHR Biomedical Research Centre (S.N., C.H.), University of Oxford, Oxford, United Kingdom; and 1st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (T.K.).
Motasim BadriFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom (N.N., S.P., V.F., T.K., S.N., C.H.); Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa (N.N., M.B.); Department of Cardiology, St.Vincent's Hospital, Darlinghurst, New South Wales, Australia (E.O., S.E., C.H.); Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia (E.O., S.E., C.H.); Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom (L.D., E.W., G.C., G.H.); Department of Physiology, Anatomy and Genetics (P.C., K.C., C.H.) and Oxford NIHR Biomedical Research Centre (S.N., C.H.), University of Oxford, Oxford, United Kingdom; and 1st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (T.K.).
Theodoros KaramitsosFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom (N.N., S.P., V.F., T.K., S.N., C.H.); Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa (N.N., M.B.); Department of Cardiology, St.Vincent's Hospital, Darlinghurst, New South Wales, Australia (E.O., S.E., C.H.); Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia (E.O., S.E., C.H.); Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom (L.D., E.W., G.C., G.H.); Department of Physiology, Anatomy and Genetics (P.C., K.C., C.H.) and Oxford NIHR Biomedical Research Centre (S.N., C.H.), University of Oxford, Oxford, United Kingdom; and 1st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (T.K.).
Sam EmmanuelFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom (N.N., S.P., V.F., T.K., S.N., C.H.); Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa (N.N., M.B.); Department of Cardiology, St.Vincent's Hospital, Darlinghurst, New South Wales, Australia (E.O., S.E., C.H.); Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia (E.O., S.E., C.H.); Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom (L.D., E.W., G.C., G.H.); Department of Physiology, Anatomy and Genetics (P.C., K.C., C.H.) and Oxford NIHR Biomedical Research Centre (S.N., C.H.), University of Oxford, Oxford, United Kingdom; and 1st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (T.K.).
Kieran ClarkeFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom (N.N., S.P., V.F., T.K., S.N., C.H.); Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa (N.N., M.B.); Department of Cardiology, St.Vincent's Hospital, Darlinghurst, New South Wales, Australia (E.O., S.E., C.H.); Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia (E.O., S.E., C.H.); Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom (L.D., E.W., G.C., G.H.); Department of Physiology, Anatomy and Genetics (P.C., K.C., C.H.) and Oxford NIHR Biomedical Research Centre (S.N., C.H.), University of Oxford, Oxford, United Kingdom; and 1st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (T.K.).
Stefan NeubauerFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom (N.N., S.P., V.F., T.K., S.N., C.H.); Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa (N.N., M.B.); Department of Cardiology, St.Vincent's Hospital, Darlinghurst, New South Wales, Australia (E.O., S.E., C.H.); Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia (E.O., S.E., C.H.); Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom (L.D., E.W., G.C., G.H.); Department of Physiology, Anatomy and Genetics (P.C., K.C., C.H.) and Oxford NIHR Biomedical Research Centre (S.N., C.H.), University of Oxford, Oxford, United Kingdom; and 1st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (T.K.).
Cameron HollowayFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom (N.N., S.P., V.F., T.K., S.N., C.H.); Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa (N.N., M.B.); Department of Cardiology, St.Vincent's Hospital, Darlinghurst, New South Wales, Australia (E.O., S.E., C.H.); Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia (E.O., S.E., C.H.); Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom (L.D., E.W., G.C., G.H.); Department of Physiology, Anatomy and Genetics (P.C., K.C., C.H.) and Oxford NIHR Biomedical Research Centre (S.N., C.H.), University of Oxford, Oxford, United Kingdom; and 1st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (T.K.). cholloway@stvincents.com.au.
Oxford BioMedica (United Kingdom) · GBSt Vincent's Hospital Sydney · AUGroote Schuur Hospital · ZAJohn Radcliffe Hospital · GBUniversity of Oxford · GBUNSW Sydney · AU

Funding

British Heart Foundation FS07/030
6 · The paper itself

Abstract

backgroundPatients with treated HIV infection have clear survival benefits although with increased cardiac morbidity and mortality. Mechanisms of heart disease may be partly related to untreated chronic inflammation. Cardiovascular magnetic resonance imaging allows a comprehensive assessment of myocardial structure, function, and tissue characterization. We investigated, using cardiovascular magnetic resonance, subclinical inflammation and myocardial disease in asymptomatic HIV-infected individuals. METHODS AND

resultsMyocardial structure and function were assessed using cardiovascular magnetic resonance at 1.5-T in treated HIV-infected individuals without known cardiovascular disease (n=103; mean age, 45±10 years) compared with healthy controls (n=92; mean age, 44±10 years). Assessments included left ventricular volumes, ejection fraction, strain, regional systolic, diastolic function, native T1 mapping, edema, and gadolinium enhancement. Compared with controls, subjects with HIV infection had 6% lower left ventricular ejection fraction (P<0.001), 7% higher myocardial mass (P=0.02), 29% lower peak diastolic strain rate (P<0.001), 4% higher short-tau inversion recovery values (P=0.02), and higher native T1 values (969 versus 956 ms in controls; P=0.01). Pericardial effusions and myocardial fibrosis were 3 and 4× more common, respectively, in subjects with HIV infection (both P<0.001).

conclusionsTreated HIV infection is associated with changes in myocardial structure and function in addition to higher rates of subclinical myocardial edema and fibrosis and frequent pericardial effusions. Chronic systemic inflammation in HIV, which involves the myocardium and pericardium, may explain the high rate of myocardial fibrosis and increased cardiac dysfunction in people living with HIV.

Indexed as

AdultAsymptomatic DiseasesCase-Control StudiesChronic DiseaseContrast MediaCross-Sectional StudiesDiastoleEdema, CardiacFemaleFibrosisHIV-1HIV InfectionsHumansMagnetic Resonance Imaging, CineMaleMiddle AgedContrast Mediacardiac functionendomyocardial fibrosisHIV-1HIV-associated cardiovascular diseasemagnetic resonance imagingpericardial effusion

Identifiers

PMID26951605
OpenAlexW2325642460

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.