Evidence map›Paper›PMID 26951603›Full record

ArticleCirculation. Cardiovascular imaging2016

Cardiac Magnetic Resonance Reveals Signs of Subclinical Myocardial Inflammation in Asymptomatic HIV-Infected Patients.

Julian A Luetkens, Jonas Doerner, Carolynne Schwarze-Zander, Jan-Christian Wasmuth, Christoph Boesecke, Alois M Sprinkart, Frederic C Schmeel, Rami Homsi, Juergen Gieseke, Hans H Schild and 2 more

2 registry-linked trialsOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Circulation. Cardiovascular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 64 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 4 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04904406 phase4completednot on this mapstarted 2020, after this paper: background citation

Changes in Weight and Body Composition After Switch to Dolutegravir/Lamivudine Compared to Continued Dolutegravir/Abacavir/Lamivudine for Virologically Suppressed HIV Infection: A Randomized Open-label Superiority Trial: AVERTAS-1

TypeinterventionalSponsorThomas BenfieldRan2020 to 2023Enrolled81ConditionsHiv, HIV Infections, HIV Cardiomyopathy, Weight Change, BodyArmsDolutegravir / Lamivudine Oral Tablet
NCT05414162 unknown statusnot on this mapstarted 2022, after this paper: background citation

Multiparametric Cardiac MRI in Oncological Patients Under Chimeric Antigen Receptor T-Cell Therapy

TypeobservationalSponsorUniversity Hospital, BonnRan2022 to 2025Enrolled60ConditionsDLBCL, Multiple Myeloma, Cytokine Release Syndrome, MyocarditisArmsCardiac MRI
3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 4 syntheses or guidelines pooled it, 106 citations in OpenAlex.

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  17. Multimodality Imaging in HIV-Associated Cardiovascular Complications: A Comprehensive Review.International journal of environmental research and public health · 2023
    Review
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Julian A LuetkensFrom the Department of Radiology (J.A.L., J.D., A.M.S., F.C.S., R.H., J.G., H.H.S., C.P.N.) and Department of Internal Medicine I (C.S.-Z., J.-C.W., C.B., J.K.R.), University of Bonn, Bonn, Germany; Department of Radiology, University Hospital Cologne, Germany (J.D.); and Philips Healthcare, Clinical Science, Hamburg, Germany (J.G.).
Jonas DoernerFrom the Department of Radiology (J.A.L., J.D., A.M.S., F.C.S., R.H., J.G., H.H.S., C.P.N.) and Department of Internal Medicine I (C.S.-Z., J.-C.W., C.B., J.K.R.), University of Bonn, Bonn, Germany; Department of Radiology, University Hospital Cologne, Germany (J.D.); and Philips Healthcare, Clinical Science, Hamburg, Germany (J.G.).
Carolynne Schwarze-ZanderFrom the Department of Radiology (J.A.L., J.D., A.M.S., F.C.S., R.H., J.G., H.H.S., C.P.N.) and Department of Internal Medicine I (C.S.-Z., J.-C.W., C.B., J.K.R.), University of Bonn, Bonn, Germany; Department of Radiology, University Hospital Cologne, Germany (J.D.); and Philips Healthcare, Clinical Science, Hamburg, Germany (J.G.).
Jan-Christian WasmuthFrom the Department of Radiology (J.A.L., J.D., A.M.S., F.C.S., R.H., J.G., H.H.S., C.P.N.) and Department of Internal Medicine I (C.S.-Z., J.-C.W., C.B., J.K.R.), University of Bonn, Bonn, Germany; Department of Radiology, University Hospital Cologne, Germany (J.D.); and Philips Healthcare, Clinical Science, Hamburg, Germany (J.G.).
Christoph BoeseckeFrom the Department of Radiology (J.A.L., J.D., A.M.S., F.C.S., R.H., J.G., H.H.S., C.P.N.) and Department of Internal Medicine I (C.S.-Z., J.-C.W., C.B., J.K.R.), University of Bonn, Bonn, Germany; Department of Radiology, University Hospital Cologne, Germany (J.D.); and Philips Healthcare, Clinical Science, Hamburg, Germany (J.G.).
Alois M SprinkartFrom the Department of Radiology (J.A.L., J.D., A.M.S., F.C.S., R.H., J.G., H.H.S., C.P.N.) and Department of Internal Medicine I (C.S.-Z., J.-C.W., C.B., J.K.R.), University of Bonn, Bonn, Germany; Department of Radiology, University Hospital Cologne, Germany (J.D.); and Philips Healthcare, Clinical Science, Hamburg, Germany (J.G.).
Frederic C SchmeelFrom the Department of Radiology (J.A.L., J.D., A.M.S., F.C.S., R.H., J.G., H.H.S., C.P.N.) and Department of Internal Medicine I (C.S.-Z., J.-C.W., C.B., J.K.R.), University of Bonn, Bonn, Germany; Department of Radiology, University Hospital Cologne, Germany (J.D.); and Philips Healthcare, Clinical Science, Hamburg, Germany (J.G.).
Rami HomsiFrom the Department of Radiology (J.A.L., J.D., A.M.S., F.C.S., R.H., J.G., H.H.S., C.P.N.) and Department of Internal Medicine I (C.S.-Z., J.-C.W., C.B., J.K.R.), University of Bonn, Bonn, Germany; Department of Radiology, University Hospital Cologne, Germany (J.D.); and Philips Healthcare, Clinical Science, Hamburg, Germany (J.G.).
Juergen GiesekeFrom the Department of Radiology (J.A.L., J.D., A.M.S., F.C.S., R.H., J.G., H.H.S., C.P.N.) and Department of Internal Medicine I (C.S.-Z., J.-C.W., C.B., J.K.R.), University of Bonn, Bonn, Germany; Department of Radiology, University Hospital Cologne, Germany (J.D.); and Philips Healthcare, Clinical Science, Hamburg, Germany (J.G.).
Hans H SchildFrom the Department of Radiology (J.A.L., J.D., A.M.S., F.C.S., R.H., J.G., H.H.S., C.P.N.) and Department of Internal Medicine I (C.S.-Z., J.-C.W., C.B., J.K.R.), University of Bonn, Bonn, Germany; Department of Radiology, University Hospital Cologne, Germany (J.D.); and Philips Healthcare, Clinical Science, Hamburg, Germany (J.G.).
Jürgen K RockstrohFrom the Department of Radiology (J.A.L., J.D., A.M.S., F.C.S., R.H., J.G., H.H.S., C.P.N.) and Department of Internal Medicine I (C.S.-Z., J.-C.W., C.B., J.K.R.), University of Bonn, Bonn, Germany; Department of Radiology, University Hospital Cologne, Germany (J.D.); and Philips Healthcare, Clinical Science, Hamburg, Germany (J.G.).
Claas P NaehleFrom the Department of Radiology (J.A.L., J.D., A.M.S., F.C.S., R.H., J.G., H.H.S., C.P.N.) and Department of Internal Medicine I (C.S.-Z., J.-C.W., C.B., J.K.R.), University of Bonn, Bonn, Germany; Department of Radiology, University Hospital Cologne, Germany (J.D.); and Philips Healthcare, Clinical Science, Hamburg, Germany (J.G.). cp@naehle.net.
University Hospital Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeople living with chronic HIV infection are at an increased risk for cardiovascular disease. With this study, we aimed to determine the extent of cardiovascular involvement in asymptomatic HIV-infected patients by a comprehensive cardiac magnetic resonance (CMR) approach. METHODS AND

resultsAsymptomatic patients with chronic HIV infection undergoing combination antiretroviral therapy (n=28) and control subjects (n=22) underwent CMR. HIV-infected patients were successfully controlled for the disease with a consistent plasma viremia of <200 copies/mL (mean CD4(+)-cell count, 475.1±307.9 cells/μL). CMR protocol allowed for the determination of cardiac function, myocardial inflammation, myocardial fibrosis, aortic stiffness, and pericardial fat volume. When compared with healthy controls, HIV-infected patients showed alterations in left ventricular function as demonstrated by a lower ejection fraction (60.9±7.1% versus 65.2±5.5%; P=0.023) and lower global peak systolic longitudinal and circumferential strain values (longitudinal strain, -17.7±3.4% versus -20.2±3.2%, circumferential strain, -21.2±4.6% versus -24.7±5.1%; P<0.001, respectively). CMR parameters indicating myocardial inflammation were elevated in HIV-infected patients (native T1 relaxation times, 1128.3±53.4 ms versus 1086.5±54.5 ms; P=0.009; relative T2 signal intensity ratio, 1.6±0.3 versus 1.4±0.3; P=0.046; early gadolinium enhancement ratio, 3.1±1.2 versus 2.1±0.6; P=0.003). Myocardial fibrosis, predominantly at the subepicardium of the midventricular and basal inferolateral wall, was prevalent in 82.1% of HIV-infected patients, but only in 27.3% of healthy controls (P<0.001).

conclusionsComprehensive CMR revealed a high burden of cardiovascular disease in asymptomatic HIV-infected patients. Subclinical myocardial inflammation as detected by CMR may be a potential precursor of the increased cardiovascular morbidity and mortality observed in patients with chronic HIV infection.

Indexed as

Magnetic Resonance ImagingAdultAgedAnti-HIV AgentsAsymptomatic DiseasesCase-Control StudiesFemaleFibrosisHIV InfectionsHumansMaleMiddle AgedMyocarditisMyocardiumPredictive Value of TestsPrognosisAnti-HIV Agentscardiovascular diseasesHIV infectionsinflammationmagnetic resonance imagingmyocarditis

Identifiers

PMID26951603
OpenAlexW2324028406

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.