ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2016
Selective Manipulation of Neural Circuits.
Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- The dorsal fan-shaped body is a neurochemically heterogeneous sleep-regulating center in Drosophila.PLoS biology · 2025Article
- Investigating the relationships of structural and functional neural networks of primary visual cortex with engineered AAVs and chemogenetic-fMRI techniques.Theranostics · 2025Article
- Ectopically expressed rhodopsin is not sensitive to X-rays.BMC neuroscience · 2024Article
- Spinal cord associative plasticity improves forelimb sensorimotor function after cervical injury.Brain : a journal of neurology · 2022Article
- Delineating the organization of projection neuron subsets in primary visual cortex with multiple fluorescent rabies virus tracing.Brain structure & function · 2021Article
- A Neural Circuit from Thalamic Paraventricular Nucleus to Central Amygdala for the Facilitation of Neuropathic Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Systematic scoping review of the concept of 'genetic identity' and its relevance for germline modification.PloS one · 2020Article
- Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity.Journal of visualized experiments : JoVE · 2019Article
- Neural Circuitry Underlying Waking Up to Hypercapnia.Frontiers in neuroscience · 2019Review
- The promise and perils of causal circuit manipulations.Current opinion in neurobiology · 2018Review
- Using Temporal Expectation to Assess Auditory Streaming in Mice.Frontiers in behavioral neuroscience · 2018Article
- Plasticity in One Hemisphere, Control From Two: Adaptation in Descending Motor Pathways After Unilateral Corticospinal Injury in Neonatal Rats.Frontiers in neural circuits · 2018Article
- Tuning the allosteric regulation of artificial muscarinic and dopaminergic ligand-gated potassium channels by protein engineering of G protein-coupled receptors.Scientific reports · 2017Article
- Neural Circuits Catch Fire.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Unraveling the complex network of neural circuits that form the nervous system demands tools that can manipulate specific circuits. The recent evolution of genetic tools to target neural circuits allows an unprecedented precision in elucidating their function. Here we describe two general approaches for achieving circuit specificity. The first uses the genetic identity of a cell, such as a transcription factor unique to a circuit, to drive expression of a molecule that can manipulate cell function. The second uses the spatial connectivity of a circuit to achieve specificity: one genetic element is introduced at the origin of a circuit and the other at its termination. When the two genetic elements combine within a neuron, they can alter its function. These two general approaches can be combined to allow manipulation of neurons with a specific genetic identity by introducing a regulatory gene into the origin or termination of the circuit. We consider the advantages and disadvantages of both these general approaches with regard to specificity and efficacy of the manipulations. We also review the genetic techniques that allow gain- and loss-of-function within specific neural circuits. These approaches introduce light-sensitive channels (optogenetic) or drug sensitive channels (chemogenetic) into neurons that form specific circuits. We compare these tools with others developed for circuit-specific manipulation and describe the advantages of each. Finally, we discuss how these tools might be applied for identification of the neural circuits that mediate behavior and for repair of neural connections.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.