Evidence map›Paper›PMID 26951497›Full record

ArticleProtein & cell2016

Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride.

Linlin Zhao, Shuqing Wang, Lingyu Du, Jyoti Dev, Liujuan Zhou, Zhijun Liu, James J Chou, Bo OuYang

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein & cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Linlin ZhaoNational Center for Protein Science, State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China.
Shuqing WangTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.
Lingyu DuNational Center for Protein Science, State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China.
Jyoti DevDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.
Liujuan ZhouNational Center for Protein Science, State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China.
Zhijun LiuNational Center for Protein Science, State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China.
James J ChouNational Center for Protein Science, State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China. james_chou@hms.harvard.edu.
Bo OuYangNational Center for Protein Science, State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China. ouyang@sibcb.ac.cn.

Funding

Function and mechanism of the HCV p7 channel and its therapeutic potentialR56AI112960 · NIAID · HARVARD MEDICAL SCHOOL · PI CHOU, JAMES JEIWEN · 2014 to 2014
$508k
NIAID NIH HHS R56 AI112960
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AmilorideBinding SitesGenotypeHepacivirusHumansMagnetic Resonance SpectroscopyMolecular Dynamics SimulationProtein Structure, TertiaryViral ProteinsViroporin Proteins5-(N,N-hexamethylene)amilorideAmiloridep7 protein, Hepatitis C virusViral ProteinsViroporin Proteins

Identifiers

PMID26951497
PMCPMC4818843

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.