Evidence map›Paper›PMID 26951462›Full record

ReviewAnnals of biomedical engineering2016

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery.

Weiwei Gao, Yue Zhang, Qiangzhe Zhang, Liangfang Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of biomedical engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  8. Review
  9. Hybrid Hydrogels in Pain Management Application: A Comprehensive Review.Clinical pharmacology : advances and applications · 2026
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  11. Article
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60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Weiwei GaoDepartment of Nanoengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
Yue ZhangDepartment of Nanoengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
Qiangzhe ZhangDepartment of Nanoengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
Liangfang ZhangDepartment of Nanoengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA. zhang@ucsd.edu.

Funding

Innate Antimicrobial Nanotherapeutics for the Treatment of H. pylori InfectionR01DK095168 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHANG, LIANGFANG · 2012 to 2016
$1.6M
NIDDK NIH HHS R01 DK095168
6 · The paper itself

Abstract

Nanoparticles have offered a unique set of properties for drug delivery including high drug loading capacity, combinatorial delivery, controlled and sustained drug release, prolonged stability and lifetime, and targeted delivery. To further enhance therapeutic index, especially for localized application, nanoparticles have been increasingly combined with hydrogels to form a hybrid biomaterial system for controlled drug delivery. Herein, we review recent progresses in engineering such nanoparticle-hydrogel hybrid system (namely 'NP-gel') with a particular focus on its application for localized drug delivery. Specifically, we highlight four research areas where NP-gel has shown great promises, including (1) passively controlled drug release, (2) stimuli-responsive drug delivery, (3) site-specific drug delivery, and (4) detoxification. Overall, integrating therapeutic nanoparticles with hydrogel technologies creates a unique and robust hybrid biomaterial system that enables effective localized drug delivery.

Indexed as

HydrogelsAnimalsDrug Delivery SystemsHumansNanoparticlesHydrogelsDrug deliveryHybrid biomaterialHydrogelNanomedicineNanoparticle

Identifiers

PMID26951462
PMCPMC4880511

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.